Seroatlas · Human Serome Atlas

QSER1

Glutamine and serine-rich protein 1

Also known as: QSER1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2KHR3
Gene: QSER1
Canonical length: 1735 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for QSER1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1735 residues, UniProt reviewed canonical sequence.

>Q2KHR3|QSER1
     1  MNFLSTAESR TAQAAASGTT LLPQFRAPSW QTGMHSSAAT ELFATGPLPS TGTLPPSLSA
    61  YQHPTTFSNR NFATTSPLVL QDSTFNTTSN GILSHHDPLL QIKTSQGTVP TALAFERLGS
   121  SVLSNSIPPQ SSTYRSAQES APHLLQPQFS LLPSALGGSQ QTPQAYSSTL FTSSTASIER
   181  ALLRECSVIK HHQRPSGTQS IQAQLTGSQH SLHSYLSNSS VVNFQETTRQ SSLSCSPIGD
   241  STQVSNGGLQ QKTSQVSVEL AQSYSSAIPS SGYPPSTTKI KSCSTEQPLT STKTPKPQSI
   301  IPPVQTLSYS KPLHNQSSVI SGQAQIYSTA QLPSLLSVSQ SQNYGLVQPH NVPSIVHSQV
   361  YRSSKVEKLP PLYKTLTFSG SSQTVTPENQ TLNYSSNQQE VLSSVTNENY PAQTRDLSSV
   421  SQSQSYSSGH SQGLSPVSQT QVSYSSQSQV LSVVSLSESY ASGESLTLTA PSLSYSSASR
   481  AQNLPDSSPT QNYISMHSSQ NVQTQESSSP QSQKFLPAVQ SSSFASSTHC QTLQNNITSP
   541  DPKSYAERKL DSDVYPSSKQ EDGFPMQELQ VLQPQASLES STQRLSDGEI NAQESTYKVS
   601  KADDRYSQSV IRSNSRLEDQ VIGVALQASK KEESVVGSVT QLNQQIGQVN NAATLDLKNS
   661  TNLIQTPQIR LNTKDLKQQH PLILKVHESK VQEQHDQIIN ASSQIQIPNH ALGHGHQASL
   721  PNTQVLLDSA CDLQILQQSI LQAGLGQVKA SLQAQRVQSP QQIVHPFLQM EGHVIQSNGD
   781  HSQQQLHPQN SEVMKMDLSE SSKPLQQHLT TKGHFSETNQ HDSKNQFVSL GSMCFPEAVL
   841  LSDERNILSN VDDILAATAA ACGVTPTDFS KSTSNETMQA VEDGDSKSHF QQSLDVRHVT
   901  SDFNSMTATV GKPQNINDTS LNGNQVTVNL SPVPALQSKM TLDQQHIETP GQNIPTKVTS
   961  AVVGPSHEVQ EQSSGPFKKQ SATNLESEED SEAPVDSTLN NNRNQEFVSS SRSISGENAT
  1021  SESEFTLGGD DSGVSMNPAR SALALLAMAQ SGDAVSVKIE EENQDLMHFN LQKKRAKGKG
  1081  QVKEEDNSNQ KQLKRPAQGK RQNPRGTDIY LPYTPPSSES CHDGYQHQEK MRQKIKEVEE
  1141  KQPEVKTGFI ASFLDFLKSG PKQQFSTLAV RMPNRTRRPG TQMVRTFCPP PLPKPSSTTP
  1201  TPLVSETGGN SPSDKVDNEL KNLEHLSSFS SDEDDPGYSQ DAYKSVSTPL TTLDATSDKK
  1261  KKTEALQVAT TSPTANTTGT ATTSSTTVGA VKQEPLHSTS YAVNILENIS SSESSKPIEL
  1321  DGLPSDQFAK GQDTVAIEGF TDEEDTESGG EGQYRERDEF VVKIEDIETF KEALKTGKEP
  1381  PAIWKVQKAL LQKFVPEIRD GQREFAATNS YLGYFGDAKS KYKRIYVKFI ENANKKEYVR
  1441  VCSKKPRNKP SQTIRTVQAK PSSSSKTSDP LASKTTTTKA PSVKPKVKQP KVKAEPPPKK
  1501  RKKWKEEFSS SQSDSSPEIH TSSSDDEEFE PPAPFVTRFL NTRAMKETFK SYMELLVSIA
  1561  LDPDTMQALE KSNDELLLPH MKKIDGMLND NRKRLLLNLH LDQSFKNALE SFPELTIITR
  1621  DSKAKSGGTA ISKIKMNGKA YNKKTLRTSK TTTKSAQEFA VDPEKIQLYS LYHSLHHYKY
  1681  HVYLICKDEI SSVQKKNEDL GQEEIVQLCM KNVKWVEDLF EKFGELLNHV QQKCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QSER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

ovary: 11 nTPM
skin: 11 nTPM
salivary gland: 9.1 nTPM
breast: 8.1 nTPM
testis: 8.1 nTPM
thyroid gland: 8 nTPM

Single-cell type

microglia: 171 nCPM
choroid plexus epithelial cells: 158 nCPM
salivary acinar cells: 145 nCPM
lactotrophs: 118 nCPM
pancreatic acinar cells: 116 nCPM
lacrimal acinar cells: 116 nCPM

Immune cell

memory B-cell: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
NK-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM

Brain region

cerebellum: 37 nTPM
choroid plexus: 28 nTPM
basal ganglia: 20 nTPM
white matter: 19 nTPM
medulla oblongata: 19 nTPM
hypothalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QSER1.

Disease | ImmuneIEDB

Conditions an epitope on QSER1 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: 1.34
DepMap mean gene effect: 0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

chromosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of QSER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TET1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QSER1 as an antibody target. Whether an autoantibody or antibody against QSER1 could matter depends on whether native QSER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QSER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label QSER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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