Seroatlas · Human Serome Atlas

QRFPR

Pyroglutamylated RF-amide peptide receptor

Also known as: GPR103, QRFPR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P65
Gene: QRFPR
Ensembl: ENSG00000186867
Chromosome: 4
Canonical length: 431 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q96P65|QRFPR
     1  MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL
    61  FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM
   121  VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM
   181  WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE
   241  LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN
   301  FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ
   361  RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE
   421  LAENSPLDSG H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QRFPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 2.1 nTPM
heart muscle: 1.2 nTPM
kidney: 1 nTPM
cerebral cortex: 0.4 nTPM
thyroid gland: 0.4 nTPM
choroid plexus: 0.3 nTPM

Single-cell type

other brain neurons: 42 nCPM
thymic myoid cells: 12 nCPM
pituicytes/fscs: 12 nCPM
early spermatids: 9.4 nCPM
late spermatids: 7.2 nCPM
cardiomyocytes: 7 nCPM

Immune cell

basophil: 1.4 nTPM
neutrophil: 1 nTPM
NK-cell: 0.4 nTPM
eosinophil: 0.2 nTPM
naive B-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

hypothalamus: 14 nTPM
pons: 7.7 nTPM
medulla oblongata: 3.6 nTPM
thalamus: 3.5 nTPM
cerebral cortex: 3.3 nTPM
midbrain: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QRFPR as an antibody target. Whether an autoantibody or antibody against QRFPR could matter depends on whether native QRFPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QRFPR is annotated at the cell surface, where native QRFPR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label QRFPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...