Seroatlas · Human Serome Atlas

PYURF

Protein preY, mitochondrial

Also known as: PreY, PREY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96I23
Gene: PYURF
Ensembl: ENSG00000145337
Chromosome: 4
Canonical length: 114 aa
Protein class: Disease related genes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q96I23|PYURF
     1  MLSGARCRLA SALRGTRAPP SAVARRCLHA SGSRPLADRG KKTEEPPRDF DPALLEFLVC
    61  PLSKKPLRYE ASTNELINEE LGIAYPIIDG IPNMIPQAAR MTRQSKKQEE VEQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYURF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 50 nTPM
liver: 49 nTPM
skeletal muscle: 48 nTPM
midbrain: 45 nTPM
breast: 45 nTPM
blood vessel: 45 nTPM

Single-cell type

papillary tip epithelial cells: 10 nCPM
podocytes: 9.3 nCPM
renal collecting duct principal cells: 8.9 nCPM
loop of henle epithelial cells: 6.8 nCPM
distal convoluted tubule cells: 5.1 nCPM
renal collecting duct intercalated cells: 5.1 nCPM

Immune cell

total PBMC: 186 nTPM
T-reg: 117 nTPM
myeloid DC: 111 nTPM
NK-cell: 109 nTPM
naive CD4 T-cell: 106 nTPM
memory CD4 T-cell: 104 nTPM

Brain region

spinal cord: 33 nTPM
white matter: 33 nTPM
cerebellum: 32 nTPM
hypothalamus: 30 nTPM
medulla oblongata: 29 nTPM
basal ganglia: 28 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PYURF.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 2 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Mitochondrial disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0.16
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.34
DepMap dependency class: selective

OntologyGO

Biological processes

protein stabilization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYURF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYURF as an antibody target. Whether an autoantibody or antibody against PYURF could matter depends on whether native PYURF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYURF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYURF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...