Seroatlas · Human Serome Atlas

PYROXD2

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

Also known as: C10orf33, FLJ23849, PYRD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2H3
Gene: PYROXD2
Ensembl: ENSG00000119943
Chromosome: 10
Canonical length: 581 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable oxidoreductase activity. Involved in mitochondrion organization. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q8N2H3|PYROXD2
     1  MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA AYLQRLGVNT
    61  AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT DLELKKHGLR LHLRNPYSFT
   121  PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA
   181  PVDMAAFQHG SLLQRMRSLS TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL
   241  KATLATDAVI GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT
   301  HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK LTPQEWLPEE
   361  FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP HHQCSIHLNC EDTLLLHQAF
   421  EDAMDGLPSH RPVIELCIPS SLDPTLAPPG CHVVSLFTQY MPYTLAGGKA WDEQERDAYA
   481  DRVFDCIEVY APGFKDSVVG RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS
   541  GYRCPLQGLY LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYROXD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 24 nTPM
thyroid gland: 15 nTPM
breast: 14 nTPM
adrenal gland: 14 nTPM
choroid plexus: 14 nTPM
fallopian tube: 13 nTPM

Single-cell type

breast lactating cells: 38 nCPM
prostatic club cells: 30 nCPM
prostatic hillock cells: 27 nCPM
ependymal cells: 25 nCPM
adrenal cortex cells: 24 nCPM
astrocytes: 24 nCPM

Immune cell

eosinophil: 191 nTPM
NK-cell: 46 nTPM
gdT-cell: 6.9 nTPM
basophil: 5.6 nTPM
memory CD8 T-cell: 5.3 nTPM
naive CD8 T-cell: 4.1 nTPM

Brain region

choroid plexus: 22 nTPM
white matter: 15 nTPM
medulla oblongata: 13 nTPM
thalamus: 13 nTPM
spinal cord: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrion organization

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYROXD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COX5B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYROXD2 as an antibody target. Whether an autoantibody or antibody against PYROXD2 could matter depends on whether native PYROXD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYROXD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PYROXD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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