COX5B

Protein identityUniProt · HPA

UniProt accession

P10606

Gene

COX5B

Ensembl

ENSG00000135940

Chromosome

2

Canonical length

129 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Transporters

Subcellular location

Mitochondria,Acrosome

OverviewNCBI Gene

Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>P10606|COX5B
     1  MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD
    61  PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY
   121  KLVPQQLAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COX5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

1,249 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.44

gnomAD pLI

0.87

gnomAD missense Z

0.39

DepMap mean gene effect

-0.4

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• mitochondrial electron transport, cytochrome c to oxygen
• respiratory gaseous exchange by respiratory system

Molecular functions

• cytochrome-c oxidase activity
• metal ion binding

Cellular components

• acrosomal vesicle
• mitochondrial inner membrane
• mitochondrial membrane
• mitochondrion
• respiratory chain complex IV

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c oxidase, subunit Vb
• Cytochrome c oxidase, subunit Vb superfamily
• Cytochrome c oxidase subunit Vb

KeywordsUniProt

• Acetylation
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion inner membrane
• Transit peptide
• Zinc

InteractionsUniProt · HPA

Protein binding partners of COX5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PYROXD2