PYDC2
Pyrin domain-containing protein 2
Also known as: POP2, PYDC2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q56P42
- Gene
- PYDC2
- Ensembl
- ENSG00000253548
- Chromosome
- 3
- Canonical length
- 97 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytosol
OverviewNCBI Gene
Involved in negative regulation of inflammatory response; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
97 residues, UniProt reviewed canonical sequence.
>Q56P42|PYDC2
1 MASSAELDFN LQALLEQLSQ DELSKFKSLI RTISLGKELQ TVPQTEVDKA NGKQLVEIFT
61 SHSCSYWAGM AAIQVFEKMN QTHLSGRADE HCVMPPPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PYDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 9.2 nTPM
- white matter: 5.1 nTPM
- basal ganglia: 3.7 nTPM
- amygdala: 1.8 nTPM
- hippocampal formation: 1.7 nTPM
- hypothalamus: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.1
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- inflammatory response
- innate immune response
- negative regulation of inflammatory response
- negative regulation of interleukin-1 beta production
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of NLRP3 inflammasome complex assembly
- negative regulation of non-canonical NF-kappaB signal transduction
- negative regulation of tumor necrosis factor-mediated signaling pathway
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PYDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PYDC2 as an antibody target. Whether an autoantibody or antibody against PYDC2 could matter depends on whether native PYDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PYDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PYDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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