PYDC1
Pyrin domain-containing protein 1
Also known as: ASC2, POP1, PYDC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXC3
- Gene
- PYDC1
- Ensembl
- ENSG00000169900
- Chromosome
- 16
- Canonical length
- 89 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Enables protein serine/threonine kinase binding activity and protein serine/threonine kinase inhibitor activity. Involved in innate immune response; negative regulation of signal transduction; and positive regulation of interleukin-1 beta production. Located in cytosol and nucleus. Part of IkappaB kinase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
89 residues, UniProt reviewed canonical sequence.
>Q8WXC3|PYDC1
1 MGTKREAILK VLENLTPEEL KKFKMKLGTV PLREGFERIP RGALGQLDIV DLTDKLVASY
61 YEDYAAELVV AVLRDMRMLE EAARLQRAALocalizationUniProt · AlphaFold · HPA
Whether an antibody against PYDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 26 nTPM
- skin: 22 nTPM
- basal ganglia: 20 nTPM
- amygdala: 19 nTPM
- cerebral cortex: 8.2 nTPM
- hypothalamus: 6.4 nTPM
Single-cell type
- suprabasal keratinocytes: 4.8 nCPM
- epicardial cells: 4.5 nCPM
- brain excitatory neurons: 3.9 nCPM
- breast hormone-responsive cells: 2.7 nCPM
- thymic myoid cells: 2.7 nCPM
- breast myoepithelial cells: 2.6 nCPM
Immune cell
- memory B-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 14 nTPM
- amygdala: 10 nTPM
- cerebral cortex: 9.3 nTPM
- basal ganglia: 7.6 nTPM
- hypothalamus: 7.4 nTPM
- midbrain: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.13
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- innate immune response
- negative regulation of canonical NF-kappaB signal transduction
- negative regulation of interleukin-1-mediated signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of interleukin-1 beta production
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PYDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PYDC1 as an antibody target. Whether an autoantibody or antibody against PYDC1 could matter depends on whether native PYDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PYDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PYDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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