PURG

Protein identityUniProt · HPA

UniProt accession

Q9UJV8

Gene

PURG

Ensembl

ENSG00000172733

Chromosome

8

Canonical length

347 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nucleoli,Plasma membrane

OverviewNCBI Gene

The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q9UJV8|PURG
     1  MERARRRGGG GGRGRGGKNV GGSGLSKSRL YPQAQHSHYP HYAASATPNQ AGGAAEIQEL
    61  ASKRVDIQKK RFYLDVKQSS RGRFLKIAEV WIGRGRQDNI RKSKLTLSLS VAAELKDCLG
   121  DFIEHYAHLG LKGHRQEHGH SKEQGSRRRQ KHSAPSPPVS VGSEEHPHSV LKTDYIERDN
   181  RKYYLDLKEN QRGRFLRIRQ TMMRGTGMIG YFGHSLGQEQ TIVLPAQGMI EFRDALVQLI
   241  EDYGEGDIEE RRGGDDDPLE LPEGTSFRVD NKRFYFDVGS NKYGIFLKVS EVRPPYRNTI
   301  TVPFKAWTRF GENFIKYEEE MRKICNSHKE KRMDGRKASG EEQECLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PURG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.3

gnomAD pLI

0.96

gnomAD missense Z

1.55

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• purine-rich negative regulatory element binding
• RNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• nucleus
• synapse

Protein domainsUniProt · Pfam · InterPro

• Purine-rich element binding protein family
• PurA ssDNA and RNA-binding protein

KeywordsUniProt

• DNA-binding
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PURG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PURB