PTOV1
Prostate tumor-overexpressed gene 1 protein
Also known as: PTOV1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86YD1
- Gene
- PTOV1
- Ensembl
- ENSG00000104960
- Chromosome
- 19
- Canonical length
- 416 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Canonical amino-acid sequenceUniProt
416 residues, UniProt reviewed canonical sequence.
>Q86YD1|PTOV1
1 MVRPRRAPYR SGAGGPLGGR GRPPRPLVVR AVRSRSWPAS PRGPQPPRIR ARSAPPMEGA
61 RVFGALGPIG PSSPGLTLGG LAVSEHRLSN KLLAWSGVLE WQEKRRPYSD STAKLKRTLP
121 CQAYVNQGEN LETDQWPQKL IMQLIPQQLL TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR
181 IMGNGFAGCM LFPHISPCEV RVLMLLYSSK KKIFMGLIPY DQSGFVSAIR QVITTRKQAV
241 GPGGVNSGPV QIVNNKFLAW SGVMEWQEPR PEPNSRSKRW LPSHVYVNQG EILRTEQWPR
301 KLYMQLIPQQ LLTTLVPLFR NSRLVQFHFT KDLETLKSLC RIMDNGFAGC VHFSYKASCE
361 IRVLMLLYSS EKKIFIGLIP HDQGNFVNGI RRVIANQQQV LQRNLEQEQQ QRGMGGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PTOV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 133 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 133 nTPM
- adrenal gland: 105 nTPM
- skeletal muscle: 103 nTPM
- cerebellum: 102 nTPM
- pituitary gland: 102 nTPM
- hypothalamus: 93 nTPM
Single-cell type
- late spermatids: 1,068 nCPM
- early spermatids: 387 nCPM
- oocytes: 230 nCPM
- epididymal principal cells: 221 nCPM
- late primary spermatocytes: 203 nCPM
- syncytiotrophoblasts: 195 nCPM
Immune cell
- basophil: 8.9 nTPM
- plasmacytoid DC: 7.7 nTPM
- neutrophil: 7.5 nTPM
- memory B-cell: 7.1 nTPM
- naive B-cell: 6.3 nTPM
- NK-cell: 4.7 nTPM
Brain region
- medulla oblongata: 138 nTPM
- white matter: 137 nTPM
- hypothalamus: 135 nTPM
- spinal cord: 133 nTPM
- choroid plexus: 128 nTPM
- midbrain: 125 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.41
- gnomAD pLI
- 0.76
- gnomAD missense Z
- -0.06
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PTOV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PTOV1 as an antibody target. Whether an autoantibody or antibody against PTOV1 could matter depends on whether native PTOV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PTOV1 is annotated at the cell surface, where native PTOV1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PTOV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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