Seroatlas · Human Serome Atlas

PTGFRN

Prostaglandin F2 receptor negative regulator

Also known as: CD315, CD9P-1, EWI-F, FLJ11001, FPRP, FPRP_HUMAN, KIAA1436, SMAP-6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2B2
Gene: PTGFRN
Ensembl: ENSG00000134247
Chromosome: 1
Canonical length: 879 aa
Protein class: CD markers, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in myoblast fusion involved in skeletal muscle regeneration. Predicted to act upstream of or within lipid droplet organization. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

879 residues, UniProt reviewed canonical sequence.

>Q9P2B2|PTGFRN
     1  MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF
    61  SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS
   121  TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH
   181  LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA
   241  DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN
   301  ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV
   361  RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF
   421  ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK
   481  QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN
   541  IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN
   601  ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW
   661  SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL
   721  DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV
   781  HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS
   841  TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGFRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 46 nTPM
smooth muscle: 44 nTPM
colon: 37 nTPM
fallopian tube: 28 nTPM
endometrium: 28 nTPM
seminal vesicle: 22 nTPM

Single-cell type

salivary myoepithelial cells: 140 nCPM
basal keratinocytes: 116 nCPM
salivary basal cells: 92 nCPM
smooth muscle cells: 81 nCPM
suprabasal keratinocytes: 71 nCPM
adrenal cortex cells: 66 nCPM

Immune cell

myeloid DC: 0.6 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 22 nTPM
cerebral cortex: 14 nTPM
midbrain: 14 nTPM
spinal cord: 14 nTPM
thalamus: 13 nTPM
basal ganglia: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTGFRN.

Disease | ImmuneIEDB

Conditions an epitope on PTGFRN was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTGFRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGFRN as an antibody target. Whether an autoantibody or antibody against PTGFRN could matter depends on whether native PTGFRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGFRN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGFRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...