Seroatlas · Human Serome Atlas

PSG8

Pregnancy-specific beta-1-glycoprotein 8

Also known as: PSG8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQ74
Gene: PSG8
Ensembl: ENSG00000124467
Chromosome: 19
Canonical length: 426 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q9UQ74|PSG8
     1  MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD VLLLVHNLPQ
    61  NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET IYSNASLLIQ NVTQEDAGSY
   121  TLHIIMGGDE NRGVTGHFTF TLYLETPKPS ISSSKLNPRE AMEAVSLTCD PETPDASYLW
   181  WMNGQSLPMS HRLQLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP
   241  KPYITINNLK PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
   301  TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP
   361  PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGKESSKSMT VKVSGKRIPV
   421  SLAIGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

placenta: 6.1 nTPM
parathyroid gland: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

syncytiotrophoblasts: 71 nCPM
oligodendrocytes: 11 nCPM
adipocytes: 10 nCPM
cone photoreceptor cells: 6.2 nCPM
early spermatids: 5.8 nCPM
late spermatids: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
amygdala: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
midbrain: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -5.37
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG8 as an antibody target. Whether an autoantibody or antibody against PSG8 could matter depends on whether native PSG8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG8 is annotated as secreted, so native PSG8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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