Seroatlas · Human Serome Atlas

PSG7

Pregnancy-specific beta-1-glycoprotein 7

Also known as: PSG7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13046
Gene: PSG7
Ensembl: ENSG00000221878
Chromosome: 19
Canonical length: 419 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q13046|PSG7
     1  MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
    61  NLTGYIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET VYSNASLLIQ NVTQEDTGSY
   121  TLHIIKRGDG TGGVTGRFTF TLYLETPKPS ISSSNFNPRE ATEAVILTCD PETPDASYLW
   181  WMNGQSLPMT HSLQLSETNR TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
   241  KPYITINNLN PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
   301  TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL YLSCFADSNP
   361  PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSVT VRVSDWTLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

placenta: 3.9 nTPM
skin: 1.1 nTPM
smooth muscle: 0.5 nTPM
breast: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

syncytiotrophoblasts: 175 nCPM
retinal ganglion cells: 7.7 nCPM
retinal bipolar cells: 7.3 nCPM
adipocytes: 2.4 nCPM
cone photoreceptor cells: 2.1 nCPM
gonadotrophs: 1.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
white matter: 1 nTPM
cerebral cortex: 0.9 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM
thalamus: 0.7 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

female pregnancy

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG7 as an antibody target. Whether an autoantibody or antibody against PSG7 could matter depends on whether native PSG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG7 is annotated as secreted, so native PSG7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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