Seroatlas · Human Serome Atlas

PSG6

Pregnancy-specific beta-1-glycoprotein 6

Also known as: PSG6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00889
Gene: PSG6
Ensembl: ENSG00000170848
Chromosome: 19
Canonical length: 435 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q00889|PSG6
     1  MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD VLLLVHNLPQ
    61  NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV YSNASLLIQN VTQEDAGSYT
   121  LHIIKRGDGT GGVTGYFTVT LYSETPKPSI SSSNLNPREV MEAVRLICDP ETPDASYLWL
   181  LNGQNLPMTH RLQLSKTNRT LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM
   241  PYITINNLNP REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT
   301  RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD LSCFADSNPP
   361  AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT GKEISKSMIV KVSETASPQV
   421  TYAGPNTWFQ EILLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

placenta: 47 nTPM
bone marrow: 1.3 nTPM
smooth muscle: 0.2 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

syncytiotrophoblasts: 592 nCPM
retinal bipolar cells: 9 nCPM
adipocytes: 8.5 nCPM
migrating cytotrophoblasts: 6.2 nCPM
extravillous trophoblasts: 4.9 nCPM
epicardial cells: 4.5 nCPM

Immune cell

neutrophil: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 5.5 nTPM
cerebral cortex: 3.7 nTPM
amygdala: 3.4 nTPM
basal ganglia: 3 nTPM
hippocampal formation: 2.7 nTPM
thalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -5.16
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

female pregnancy

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG6 as an antibody target. Whether an autoantibody or antibody against PSG6 could matter depends on whether native PSG6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG6 is annotated as secreted, so native PSG6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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