Seroatlas · Human Serome Atlas

PSG4

Pregnancy-specific beta-1-glycoprotein 4

Also known as: PSG4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00888
Gene: PSG4
Ensembl: ENSG00000243137
Chromosome: 19
Canonical length: 419 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q00888|PSG4
     1  MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
    61  NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY
   121  TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW
   181  WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS
   241  KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV
   301  TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP
   361  RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

placenta: 136 nTPM
parathyroid gland: 52 nTPM
skin: 3.1 nTPM
salivary gland: 1.3 nTPM
breast: 1 nTPM
smooth muscle: 1 nTPM

Single-cell type

syncytiotrophoblasts: 732 nCPM
esophageal apical cells: 27 nCPM
endometrial glandular cells: 26 nCPM
epididymal basal cells: 25 nCPM
epididymal efferent duct absorptive cells: 25 nCPM
extravillous trophoblasts: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.1 nTPM
cerebral cortex: 1.8 nTPM
white matter: 1.6 nTPM
amygdala: 1.4 nTPM
basal ganglia: 1.2 nTPM
thalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -4.21
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

female pregnancy

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG4 as an antibody target. Whether an autoantibody or antibody against PSG4 could matter depends on whether native PSG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG4 is annotated as secreted, so native PSG4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...