Seroatlas · Human Serome Atlas

PSG3

Pregnancy-specific beta-1-glycoprotein 3

Also known as: PSG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16557
Gene: PSG3
Ensembl: ENSG00000221826
Chromosome: 19
Canonical length: 428 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q16557|PSG3
     1  MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD VLLLVHNLPQ
    61  NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY
   121  TLHIVKRGDG TRGETGHFTF TLYLETPKPS ISSSNLYPRE DMEAVSLTCD PETPDASYLW
   181  WMNGQSLPMT HSLQLSKNKR TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
   241  KPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
   301  TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL YLSCFADSNP
   361  PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGMESSKSMT VKVSAPSGTG
   421  HLPGLNPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 134 nTPM

Expression across tissuesHPA

Tissue

placenta: 134 nTPM
smooth muscle: 0.6 nTPM
testis: 0.6 nTPM
spleen: 0.3 nTPM
endometrium: 0.1 nTPM
pancreas: 0.1 nTPM

Single-cell type

syncytiotrophoblasts: 2,113 nCPM
extravillous trophoblasts: 24 nCPM
adipocytes: 23 nCPM
migrating cytotrophoblasts: 16 nCPM
cone photoreceptor cells: 12 nCPM
late primary spermatocytes: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -5.18
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG3 as an antibody target. Whether an autoantibody or antibody against PSG3 could matter depends on whether native PSG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG3 is annotated as secreted, so native PSG3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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