Seroatlas · Human Serome Atlas

PSG2

Pregnancy-specific beta-1-glycoprotein 2

Also known as: CEA, PSBG2, PSG1, PSG2_HUMAN, PSGGB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11465
Gene: PSG2
Ensembl: ENSG00000242221
Chromosome: 19
Canonical length: 335 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>P11465|PSG2
     1  MGPLSAPPCT EHIKWKGLLV TASLLNFWNL PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
    61  NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET AYSNASLLIQ NVTREDAGSY
   121  TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCD PETPDTSYQW
   181  WMNGQSLPMT HRFQLSETNR TLFLFGVTKY TAGPYECEIR NSGSASRSDP VTLNLLHGPD
   241  LPRIHPSYTN YRSGDNLYLS CFANSNPPAQ YSWTINGKFQ QSGQNLFIPQ ITTKHSGLYV
   301  CSVRNSATGE ESSTSLTVKV SASTRIGLLP LLNPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 225 nTPM

Expression across tissuesHPA

Tissue

placenta: 225 nTPM
smooth muscle: 0.9 nTPM
bone marrow: 0.7 nTPM
spleen: 0.4 nTPM
skin: 0.3 nTPM
lung: 0.2 nTPM

Single-cell type

syncytiotrophoblasts: 1,086 nCPM
extravillous trophoblasts: 52 nCPM
migrating cytotrophoblasts: 27 nCPM
retinal bipolar cells: 8 nCPM
adipocytes: 4.3 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 4.8 nTPM
cerebral cortex: 3.9 nTPM
amygdala: 2.9 nTPM
spinal cord: 2.5 nTPM
basal ganglia: 2.4 nTPM
hippocampal formation: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -4.82
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSG2 as an antibody target. Whether an autoantibody or antibody against PSG2 could matter depends on whether native PSG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSG2 is annotated as secreted, so native PSG2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PSG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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