Seroatlas · Human Serome Atlas

PSD3

PH and SEC7 domain-containing protein 3

Also known as: DKFZp761K1423, EFA6D, EFA6R, HCA67, KIAA0942, PSD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYI0
Gene: PSD3
Ensembl: ENSG00000156011
Chromosome: 8
Canonical length: 1048 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol,Calyx,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse; postsynapse; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1048 residues, UniProt reviewed canonical sequence.

>Q9NYI0|PSD3
     1  MEGRSAAAET FVWVNNASAH SQSVAKAKYE FLFGRSEGKA PDTSDHGGST LLPPNVTNEF
    61  PEYGTMEEGG EGLRASLEFD GEALPCHPQE QQGVQPLTGC HSGLDSVTEG PKDVREAPSQ
   121  SHLKEQSLQP IDSLISALKA TEARIISGTL QATKVLDQDA VSSFSVQQVE KELDTASRKT
   181  QRVNKTLPAG QKNLPEIPLS AEVTTEESFY LSIQKDLTAL LTGDTQAEIS QIMNNGRKGA
   241  VCVQEPSCPL ASLGSSAVTC HSAGSVGFLK EQRSALGREH PGGCDRSSSM GRPGRVKHVE
   301  FQGVEILWTG GDKRETQHPI DFETSLQRTA SPDSKESSKV PRHLISSAGL CNSSSLTENV
   361  WDESWKAPSE RPGTSSGTFS PVRLDESGED EVFLQENKQH LEKTPKPERD RERISEQEEH
   421  VKGEDEDILG PGYTEDSTDV YSSQFETILD NTSLYYSAES LETLYSEPDS YFSFEMPLTP
   481  MIQQRIKEGG QFLERTSGGG HQDILSVSAD GGIVMGYSSG VTNGLNDASD SIYTKGTPEI
   541  AFWGSNAGVK TTRLEAHSEM GSTEILEKET PENLSNGTSS NVEAAKRLAK RLYQLDRFKR
   601  SDVAKHLGKN NEFSKLVAEE YLKFFDFTGM TLDQSLRYFF KAFSLVGETQ ERERVLIHFS
   661  NRYFYCNPDT IASQDGVHCL TCAIMLLNTD LHGHVNIGKK MTCQEFIANL QGVNEGVDFS
   721  KDLLKALYNS IKNEKLEWAV DDEEKKKSPS ESTEEKANGT HPKTISRIGS TTNPFLDIPH
   781  DPNAAVYKSG FLARKIHADM DGKKTPRGKR GWKTFYAVLK GTVLYLQKDE YKPEKALSEE
   841  DLKNAVSVHH ALASKATDYE KKPNVFKLKT ADWRVLLFQT QSPEEMQGWI NKINCVAAVF
   901  SAPPFPAAIG SQKKFSRPLL PATTTKLSQE EQLKSHESKL KQITTELAEH RSYPPDKKVK
   961  AKDVDEYKLK DHYLEFEKTR YEMYVSILKE GGKELLSNDE SEAAGLKKSH SSPSLNPDTS
  1021  PITAKVKRNV SERKDHRPET PSIKQKVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 65 nTPM
cerebral cortex: 48 nTPM
basal ganglia: 26 nTPM
heart muscle: 26 nTPM
hippocampal formation: 19 nTPM
amygdala: 19 nTPM

Single-cell type

adrenal cortex cells: 1,568 nCPM
bergmann glia: 1,488 nCPM
somatotrophs: 1,346 nCPM
cardiomyocytes: 1,236 nCPM
early spermatids: 1,018 nCPM
foveolar cells: 966 nCPM

Immune cell

basophil: 0.5 nTPM
naive B-cell: 0.5 nTPM
T-reg: 0.4 nTPM
memory B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 215 nTPM
cerebral cortex: 192 nTPM
basal ganglia: 176 nTPM
hippocampal formation: 145 nTPM
amygdala: 129 nTPM
white matter: 117 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.01
gnomAD missense Z: -1.5
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of ARF protein signal transduction

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YWHAZ

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSD3 as an antibody target. Whether an autoantibody or antibody against PSD3 could matter depends on whether native PSD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSD3 is annotated at the cell surface, where native PSD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PSD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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