Seroatlas · Human Serome Atlas

PRXL2C

Peroxiredoxin-like 2C

Also known as: AAED1, C9orf21, PXL2C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7RTV5
Gene
PRXL2C
Ensembl
ENSG00000158122
Chromosome
9
Canonical length
226 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q7RTV5|PRXL2C
     1  MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG ALFRERRAVV
    61  VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS YHHIEPFCKL TGYSHEIYVD
   121  PEREIYKRLG MKRGEEIASS GQSPHIKSNL LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL
   181  ILGPGNNIHF IHRDRNRLDH KPINSVLQLV GVQHVNFTNR PSVIHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRXL2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 13 nTPM
  • adipose tissue: 13 nTPM
  • bone marrow: 11 nTPM
  • skeletal muscle: 11 nTPM
  • smooth muscle: 10 nTPM
  • breast: 9.7 nTPM

Single-cell type

  • megakaryocytes: 105 nCPM
  • extravillous trophoblasts: 93 nCPM
  • fallopian tube ciliated cells: 92 nCPM
  • hofbauer cells: 81 nCPM
  • mast cells: 74 nCPM
  • smooth muscle cells: 74 nCPM

Immune cell

  • basophil: 46 nTPM
  • eosinophil: 23 nTPM
  • intermediate monocyte: 11 nTPM
  • non-classical monocyte: 11 nTPM
  • MAIT T-cell: 11 nTPM
  • T-reg: 11 nTPM

Brain region

  • medulla oblongata: 11 nTPM
  • white matter: 9.8 nTPM
  • spinal cord: 8.8 nTPM
  • thalamus: 8.8 nTPM
  • pons: 8.3 nTPM
  • midbrain: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRXL2C as an antibody target. Whether an autoantibody or antibody against PRXL2C could matter depends on whether native PRXL2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRXL2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRXL2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRXL2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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