Seroatlas · Human Serome Atlas

PRXL2B

Prostamide/prostaglandin F synthase

Also known as: C1orf93, FAM213B, MGC26818, PXL2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBF2
Gene: PRXL2B
Ensembl: ENSG00000157870
Chromosome: 1
Canonical length: 198 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable prostaglandin F synthase activity and thioredoxin peroxidase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in extracellular exosome and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q8TBF2|PRXL2B
     1  MSTVDLARVG ACILKHAVTG EAVELRSLWR EHACVVAGLR RFGCVVCRWI AQDLSSLAGL
    61  LDQHGVRLVG VGPEALGLQE FLDGDYFAGE LYLDESKQLY KELGFKRYNS LSILPAALGK
   121  PVRDVAAKAK AVGIQGNLSG DLLQSGGLLV VSKGGDKVLL HFVQKSPGDY VPKEHILQVL
   181  GISAEVCASD PPQCDREV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRXL2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 41 nTPM
amygdala: 27 nTPM
hypothalamus: 27 nTPM
hippocampal formation: 26 nTPM
basal ganglia: 26 nTPM
colon: 23 nTPM

Single-cell type

other brain neurons: 13 nCPM
gastric progenitor cells: 13 nCPM
enterocytes: 12 nCPM
renal collecting duct principal cells: 11 nCPM
ependymal cells: 9.4 nCPM
papillary tip epithelial cells: 9.3 nCPM

Immune cell

NK-cell: 4.9 nTPM
T-reg: 4.3 nTPM
MAIT T-cell: 4.2 nTPM
naive CD8 T-cell: 3.7 nTPM
memory CD8 T-cell: 2.9 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebral cortex: 28 nTPM
pons: 26 nTPM
basal ganglia: 26 nTPM
hypothalamus: 24 nTPM
hippocampal formation: 22 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRXL2B as an antibody target. Whether an autoantibody or antibody against PRXL2B could matter depends on whether native PRXL2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRXL2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRXL2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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