Seroatlas · Human Serome Atlas

PRRT1B

Proline rich transmembrane protein 1B

Also known as: DSPD2, IFITMD8, PRT1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GWB2
Gene: PRRT1B
Ensembl: ENSG00000283526
Chromosome: 9
Canonical length: 263 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>A0A1B0GWB2|PRRT1B
     1  MEAGAGGAGS DTKGGGSPAT PEDPRSPAKP AAPEDPQMPA QPALPQLPRR PRTLDEDGAP
    61  SEDGAAGGSE PAPEDAPAQA AGEAGPVSKA AAGGAPHIGF VGEPPPYAPP DPKAAPLLYP
   121  PFPQVPVVLQ PAPSALFPPP AQLYPAAPTP PALFSPPAGA AFPFPVYNGP MAGVPGPATV
   181  EHRPLPKDYM MESVLVTLFC CLLTGLIAIV YSHEARAALG RGDLAQAEEA SRKARSLVLF
   241  SLLFGVFVST SWVIYVVVAL YLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRT1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 7 nTPM
lung: 5.1 nTPM
pancreas: 4.5 nTPM
liver: 3.8 nTPM
prostate: 3.2 nTPM
stomach: 2.8 nTPM

Single-cell type

fallopian tube ciliated cells: 21 nCPM
respiratory ciliated cells: 17 nCPM
pancreatic islet cells: 8.9 nCPM
parietal cells: 8.8 nCPM
endometrial ciliated cells: 8.4 nCPM
neuroendocrine cells: 8.2 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

basal ganglia: 3.4 nTPM
cerebellum: 3.3 nTPM
cerebral cortex: 2.4 nTPM
amygdala: 2.1 nTPM
hippocampal formation: 2 nTPM
midbrain: 2 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRT1B as an antibody target. Whether an autoantibody or antibody against PRRT1B could matter depends on whether native PRRT1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRT1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRT1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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