Seroatlas · Human Serome Atlas

PRRT1

Proline-rich transmembrane protein 1

Also known as: C6orf31, DSPD1, IFITMD7, NG5, PRRT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99946
Gene: PRRT1
Ensembl: ENSG00000204314
Chromosome: 6
Canonical length: 306 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA receptor activity. Predicted to act upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Predicted to be located in plasma membrane and synaptic vesicle membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q99946|PRRT1
     1  MSSEKSGLPD SVPHTSPPPY NAPQPPAEPP APPPQAAPSS HHHHHHHYHQ SGTATLPRLG
    61  AGGLASSAAT AQRGPSSSAT LPRPPHHAPP GPAAGAPPPG CATLPRMPPD PYLQETRFEG
   121  PLPPPPPAAA APPPPAPAQT AQAPGFVVPT HAGTVGTLPL GGYVAPGYPL QLQPCTAYVP
   181  VYPVGTPYAG GTPGGTGVTS TLPPPPQGPG LALLEPRRPP HDYMPIAVLT TICCFWPTGI
   241  IAIFKAVQVR TALARGDMVS AEIASREARN FSFISLAVGI AAMVLCTILT VVIIIAAQHH
   301  ENYWDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 67 nTPM
cerebral cortex: 51 nTPM
basal ganglia: 29 nTPM
hippocampal formation: 27 nTPM
amygdala: 19 nTPM
hypothalamus: 18 nTPM

Single-cell type

brain excitatory neurons: 27 nCPM
brain inhibitory neurons: 23 nCPM
other brain neurons: 21 nCPM
oligodendrocytes: 9.7 nCPM
oligodendrocyte progenitor cells: 9.2 nCPM
ependymal cells: 8.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 134 nTPM
hippocampal formation: 133 nTPM
cerebral cortex: 112 nTPM
white matter: 63 nTPM
thalamus: 37 nTPM
basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.3
gnomAD missense Z: 3.03
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRT1 as an antibody target. Whether an autoantibody or antibody against PRRT1 could matter depends on whether native PRRT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRT1 is annotated at the cell surface, where native PRRT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRRT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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