PRR5

Protein identityUniProt · HPA

UniProt accession

P85299

Gene

PRR5

Ensembl

ENSG00000186654

Chromosome

22

Canonical length

388 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>P85299|PRR5
     1  MRTLRRLKFM SSPSLSDLGK REPAAAADER GTQQRRACAN ATWNSIHNGV IAVFQRKGLP
    61  DQELFSLNEG VRQLLKTELG SFFTEYLQNQ LLTKGMVILR DKIRFYEGQK LLDSLAETWD
   121  FFFSDVLPML QAIFYPVQGK EPSVRQLALL HFRNAITLSV KLEDALARAH ARVPPAIVQM
   181  LLVLQGVHES RGVTEDYLRL ETLVQKVVSP YLGTYGLHSS EGPFTHSCIL EKRLLRRSRS
   241  GDVLAKNPVV RSKSYNTPLL NPVQEHEAEG AAAGGTSIRR HSVSEMTSCP EPQGFSDPPG
   301  QGPTGTFRSS PAPHSGPCPS RLYPTTQPPE QGLDPTRSSL PRSSPENLVD QILESVDSDS
   361  EGIFIDFGRG RGSGMSDLEG SGGRQSVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

19 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.07

gnomAD missense Z

-0.24

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to nutrient levels
• cytoskeleton organization
• negative regulation of apoptotic process
• phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of cell growth
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• TORC2 signaling

Cellular components

• cytosol
• TORC2 complex

Protein domainsUniProt · Pfam · InterPro

• TORC2 component Bit61/PRR5
• Cullin repeat-like-containing domain superfamily
• HbrB-like

KeywordsUniProt

• Cell cycle
• Phosphoprotein
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of PRR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MTOR
• YWHAH