Seroatlas · Human Serome Atlas

PROKR2

Prokineticin receptor 2

Also known as: dJ680N4.3, GPR73b, GPR73L1, GPRg2, KAL3, PKR2, PKR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFJ6
Gene
PROKR2
Ensembl
ENSG00000101292
Chromosome
20
Canonical length
384 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q8NFJ6|PROKR2
     1  MAAQNGNTSF TPNFNPPQDH ASSLSFNFSY GDYDLPMDED EDMTKTRTFF AAKIVIGIAL
    61  AGIMLVCGIG NFVFIAALTR YKKLRNLTNL LIANLAISDF LVAIICCPFE MDYYVVRQLS
   121  WEHGHVLCAS VNYLRTVSLY VSTNALLAIA IDRYLAIVHP LKPRMNYQTA SFLIALVWMV
   181  SILIAIPSAY FATETVLFIV KSQEKIFCGQ IWPVDQQLYY KSYFLFIFGV EFVGPVVTMT
   241  LCYARISREL WFKAVPGFQT EQIRKRLRCR RKTVLVLMCI LTAYVLCWAP FYGFTIVRDF
   301  FPTVFVKEKH YLTAFYVVEC IAMSNSMINT VCFVTVKNNT MKYFKKMMLL HWRPSQRGSK
   361  SSADLDLRTN GVPTTEEVDC IRLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROKR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
1.5 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 1.5 nTPM
  • bone marrow: 0.7 nTPM
  • retina: 0.5 nTPM
  • hippocampal formation: 0.4 nTPM
  • lymph node: 0.4 nTPM
  • testis: 0.3 nTPM

Single-cell type

  • cardiomyocytes: 38 nCPM
  • salivary duct cells: 15 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • neutrophils: 3.4 nCPM
  • late primary spermatocytes: 2.7 nCPM
  • epididymal clear cells: 2 nCPM

Immune cell

  • basophil: 1.2 nTPM
  • neutrophil: 1 nTPM
  • naive B-cell: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM

Brain region

  • midbrain: 6.7 nTPM
  • basal ganglia: 5.4 nTPM
  • cerebral cortex: 5 nTPM
  • hippocampal formation: 5 nTPM
  • white matter: 3.6 nTPM
  • cerebellum: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PROKR2.

Disease | AllUniProt

Conditions PROKR2 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 3 with or without anosmia (HH3) MIM:244200

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 251 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROKR2 as an antibody target. Whether an autoantibody or antibody against PROKR2 could matter depends on whether native PROKR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROKR2 is annotated at the cell surface, where native PROKR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PROKR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PROKR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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