Seroatlas · Human Serome Atlas

PROKR1

Prokineticin receptor 1

Also known as: GPR73, GPR73a, PKR1, PKR1_HUMAN, ZAQ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCW9
Gene: PROKR1
Ensembl: ENSG00000169618
Chromosome: 2
Canonical length: 393 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q8TCW9|PROKR1
     1  METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE DVTNSRTFFA
    61  AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL IANLAISDFL VAIVCCPFEM
   121  DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV STNALLAIAI DRYLAIVHPL RPRMKCQTAT
   181  GLIALVWTVS ILIAIPSAYF TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE
   241  FVGPVVTMTL CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF
   301  YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV KYFKKIMLLH
   361  WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROKR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

epididymis: 3.3 nTPM
adipose tissue: 1.5 nTPM
adrenal gland: 1 nTPM
breast: 0.5 nTPM
pituitary gland: 0.5 nTPM
testis: 0.3 nTPM

Single-cell type

adrenal medulla cells: 11 nCPM
late spermatids: 3 nCPM
pituitary stem cells: 2.9 nCPM
epididymal principal cells: 1.9 nCPM
early spermatids: 0.8 nCPM
vascular endothelial cells: 0.3 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.6 nTPM
medulla oblongata: 1.3 nTPM
pons: 1.2 nTPM
spinal cord: 1 nTPM
midbrain: 0.9 nTPM
cerebellum: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROKR1 as an antibody target. Whether an autoantibody or antibody against PROKR1 could matter depends on whether native PROKR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROKR1 is annotated at the cell surface, where native PROKR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PROKR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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