Seroatlas · Human Serome Atlas

PRKRIP1

PRKR-interacting protein 1

Also known as: C114, FLJ13902, KRBOX3, PKRI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H875
Gene: PRKRIP1
Ensembl: ENSG00000128563
Chromosome: 7
Canonical length: 184 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q9H875|PRKRIP1
     1  MASPAASSVR PPRPKKEPQT LVIPKNAAEE QKLKLERLMK NPDKAVPIPE KMSEWAPRPP
    61  PEFVRDVMGS SAGAGSGEFH VYRHLRRREY QRQDYMDAMA EKQKLDAEFQ KRLEKNKIAA
   121  EEQTAKRRKK RQKLKEKKLL AKKMKLEQKK QEGPGQPKEQ GSSSSAEASG TEEEEEVPSF
   181  TMGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKRIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
testis: 18 nTPM
skin: 17 nTPM
spleen: 17 nTPM
spinal cord: 16 nTPM
hypothalamus: 16 nTPM

Single-cell type

myonuclei: 295 nCPM
proximal tubule cells: 189 nCPM
late primary spermatocytes: 145 nCPM
renal connecting tubule cells: 140 nCPM
distal convoluted tubule cells: 139 nCPM
choroid plexus epithelial cells: 134 nCPM

Immune cell

neutrophil: 21 nTPM
eosinophil: 18 nTPM
naive CD4 T-cell: 14 nTPM
plasmacytoid DC: 14 nTPM
memory B-cell: 14 nTPM
non-classical monocyte: 14 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 12 nTPM
white matter: 12 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PRKR-interacting protein 1
Protein of unknown function (DUF1168)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKRIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EIF2AK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKRIP1 as an antibody target. Whether an autoantibody or antibody against PRKRIP1 could matter depends on whether native PRKRIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKRIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKRIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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