PRDX5

Protein identityUniProt · HPA

UniProt accession

P30044

Gene

PRDX5

Ensembl

ENSG00000126432

Chromosome

11

Canonical length

214 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>P30044|PRDX5
     1  MGLAGVCALR RSAGYILVGG AGGQSAAAAA RRYSEGEWAS GGVRSFSRAA AAMAPIKVGD
    61  AIPAVEVFEG EPGNKVNLAE LFKGKKGVLF GVPGAFTPGC SKTHLPGFVE QAEALKAKGV
   121  QVVACLSVND AFVTGEWGRA HKAEGKVRLL ADPTGAFGKE TDLLLDDSLV SIFGNRRLKR
   181  FSMVVQDGIV KALNVEPDGT GLTCSLAPNI ISQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

1,322 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDX5.

Disease | ImmuneIEDB

Conditions an epitope on PRDX5 was assayed in.

• melanoma T cell
• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

0.08

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell redox homeostasis
• cellular response to oxidative stress
• cellular response to reactive oxygen species
• hydrogen peroxide catabolic process
• inflammatory response
• negative regulation of apoptotic process
• negative regulation of oxidoreductase activity
• negative regulation of transcription by RNA polymerase III
• positive regulation of collagen biosynthetic process
• regulation of apoptosis involved in tissue homeostasis
• response to oxidative stress
• reactive nitrogen species metabolic process

Molecular functions

• antioxidant activity
• cysteine-type endopeptidase inhibitor activity involved in apoptotic process
• identical protein binding
• peroxidase activity
• signaling receptor binding
• thioredoxin peroxidase activity
• peroxynitrite reductase activity
• RNA polymerase III transcription regulatory region sequence-specific DNA binding

Cellular components

• cytoplasm
• cytoplasmic vesicle
• cytosol
• extracellular exosome
• extracellular space
• intracellular membrane-bounded organelle
• mitochondrial matrix
• mitochondrion
• nucleus
• perinuclear region of cytoplasm
• peroxisomal matrix
• peroxisome

Protein domainsUniProt · Pfam · InterPro

• Thioredoxin domain
• Thioredoxin-like superfamily
• Redoxin
• Peroxiredoxin-5-like
• Redoxin

KeywordsUniProt

• Acetylation
• Alternative initiation
• Antioxidant
• Cytoplasm
• Disulfide bond
• Lipoprotein
• Mitochondrion
• Oxidoreductase
• Palmitate
• Peroxidase
• Peroxisome
• Phosphoprotein
• Redox-active center
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of PRDX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SOD1