Seroatlas · Human Serome Atlas

PRDM11

PR domain-containing protein 11

Also known as: PFM8, PRD11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQV5
Gene: PRDM11
Ensembl: ENSG00000019485
Chromosome: 11
Canonical length: 511 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of cell growth; positive regulation of fibroblast apoptotic process; and regulation of DNA-templated transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>Q9NQV5|PRDM11
     1  MLKMAEPIAS LMIVECRACL RCSPLFLYQR EKDRMTENMK ECLAQTNAAV GDMVTVVKTE
    61  VCSPLRDQEY GQPCSRRPDS SAMEVEPKKL KGKRDLIVPK SFQQVDFWFC ESCQEYFVDE
   121  CPNHGPPVFV SDTPVPVGIP DRAALTIPQG MEVVKDTSGE SDVRCVNEVI PKGHIFGPYE
   181  GQISTQDKSA GFFSWLIVDK NNRYKSIDGS DETKANWMRY VVISREEREQ NLLAFQHSER
   241  IYFRACRDIR PGEWLRVWYS EDYMKRLHSM SQETIHRNLA RGEKRLQREK SEQVLDNPED
   301  LRGPIHLSVL RQGKSPYKRG FDEGDVHPQA KKKKIDLIFK DVLEASLESA KVEAHQLALS
   361  TSLVIRKVPK YQDDAYSQCA TTMTHGVQNI GQTQGEGDWK VPQGVSKEPG QLEDEEEEPS
   421  SFKADSPAEA SLASDPHELP TTSFCPNCIR LKKKVRELQA ELDMLKSGKL PEPPVLPPQV
   481  LELPEFSDPA GKLVWMRLLS EGRVRSGLCG G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDM11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 11 nTPM
endometrium: 9.6 nTPM
cervix: 9.3 nTPM
cerebral cortex: 8.5 nTPM
heart muscle: 8.3 nTPM
colon: 8.2 nTPM

Single-cell type

microglia: 294 nCPM
late spermatids: 85 nCPM
respiratory ciliated cells: 48 nCPM
early spermatids: 46 nCPM
pituicytes/fscs: 44 nCPM
thyrotrophs: 42 nCPM

Immune cell

MAIT T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
eosinophil: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

cerebral cortex: 21 nTPM
amygdala: 18 nTPM
hypothalamus: 17 nTPM
thalamus: 17 nTPM
midbrain: 16 nTPM
white matter: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SET domain
SET domain superfamily
Zinc finger PRDM4/PRDM1/PRDM14-like
PR domain zinc finger protein 2, PR domain
PRDM11, PR/SET domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRDM11 as an antibody target. Whether an autoantibody or antibody against PRDM11 could matter depends on whether native PRDM11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRDM11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRDM11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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