Seroatlas · Human Serome Atlas

PRDM10

PR domain zinc finger protein 10

Also known as: KIAA1231, MGC131802, PFM7, PRD10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQV6
Gene: PRDM10
Ensembl: ENSG00000170325
Chromosome: 11
Canonical length: 1147 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1147 residues, UniProt reviewed canonical sequence.

>Q9NQV6|PRDM10
     1  MDSKDESSHV WPTSAEHEQN AAQVHFVPDT GTVAQIVYTD DQVRPPQQVV YTADGASYTS
    61  VDGPEHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL
   121  ATLQTPLGRL EAKEEEDEDE DEDTEEDEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN
   181  AHASVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL
   241  VRGSELKDCY IHLKVSLDKG DRKERDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA
   301  YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNQKIHDI SEEERKVLRE QEKNWPCYEC
   361  NRRFISSEQL QQHLNSHDEK LDVFSRTRGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN
   421  GEKSDDGTQD LLHFPTKEQF DEAEPATLNG LDQPEQTTIP IPQLPQETQS SLEHEPETHT
   481  LHLQPQHEES VVPTQSTLTA DDMRRAKRIR LELQNAALQH LFIRKSFRPF KCLQCGKAFR
   541  EKDKLDQHLR FHGREGNCPL TCDLCNKGFI SSTSLESHMK LHSDQKTYSC IFCPESFDRL
   601  DLLKDHVAIH INDGYFTCPT CKKRFPDFIQ VKKHVRSFHS EKIYQCTECD KAFCRPDKLR
   661  LHMLRHSDRK DFLCSTCGKQ FKRKDKLREH MQRMHNPERE AKKADRISRS KTFKPRITST
   721  DYDSFTFKCR LCMMGFRRRG MLVNHLSKRH PDMKIEEVPE LTLPIIKPNR DYFCQYCDKV
   781  YKSASKRKAH ILKNHPGAEL PPSIRKLRPA GPGEPDPMLS THTQLTGTIA TPPVCCPHCS
   841  KQYSSKTKMV QHIRKKHPEF AQLSNTIHTP LTTAVISATP AVLTTDSATG ETVVTTDLLT
   901  QAMTELSQTL TTDYRTPQGD YQRIQYIPVS QSASGLQQPQ HIQLQVVQVA SATSPHQSQQ
   961  STVDVGQLHD PQPYPQHAIQ VQHIQVSGQP LSPSAQQAQQ GLSPSHIQGS SSTQGQALQQ
  1021  QQQQQQNSSV QHTYLPSAWN SFRGYSSEIQ MMTLPPGQFV ITDSGVATPV TTGQVKAVTS
  1081  GHYVLSESQS ELEEKQTSAL SGGVQVEPPA HSDSLDPQTN SQQQTTQYII TTTTNGNGSS
  1141  EVHITKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.1 nTPM
bone marrow: 7.4 nTPM
skeletal muscle: 6.4 nTPM
thymus: 6.3 nTPM
skin: 5.9 nTPM
retina: 4.4 nTPM

Single-cell type

neutrophils: 106 nCPM
myonuclei: 77 nCPM
gonadotrophs: 55 nCPM
neutrophil progenitors: 54 nCPM
distal convoluted tubule cells: 51 nCPM
choroid plexus epithelial cells: 49 nCPM

Immune cell

memory B-cell: 6.8 nTPM
neutrophil: 6.4 nTPM
eosinophil: 6 nTPM
NK-cell: 4.4 nTPM
naive B-cell: 3.6 nTPM
naive CD4 T-cell: 3.1 nTPM

Brain region

cerebellum: 25 nTPM
white matter: 18 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 17 nTPM
choroid plexus: 16 nTPM
basal ganglia: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDM10.

Disease | AllUniProt

Conditions PRDM10 is implicated in, by any mechanism.

Birt-Hogg-Dube syndrome 2 (BHD2) MIM:620459

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.15
gnomAD missense Z: 3.28
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRDM10 as an antibody target. Whether an autoantibody or antibody against PRDM10 could matter depends on whether native PRDM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRDM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRDM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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