PPP2R3B

Protein identityUniProt · HPA

UniProt accession

Q9Y5P8

Gene

PPP2R3B

Ensembl

ENSG00000167393

Chromosome

X

Canonical length

575 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Primary cilium,Primary cilium tip,Cytosol

OverviewNCBI Gene

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q9Y5P8|PPP2R3B
     1  MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG DGEQPGAWPT
    61  APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT RRSAGTRVVQ TRKEEPLPPA
   121  TSQSIPTFYF PRGRPQDSVN VDAVISKIES TFARFPHERA TMDDMGLVAK ACGCPLYWKG
   181  PLFYGAGGER TGSVSVHKFV AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD
   241  VVNTHPGLSF LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE
   301  EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK MIDRIFSGAV
   361  TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM DLDGDGALSM FELEYFYEEQ
   421  CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE GKITLQDLKR CKLANVFFDT FFNIEKYLDH
   481  EQKEQISLLR DGDSGGPELS DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA
   541  LRSPLAQRPF FEAPSPLGAV DLYEYACGDE DLEPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

87 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0

gnomAD missense Z

-1.4

OntologyGO

Biological processes

• protein dephosphorylation
• regulation of cell cycle

Molecular functions

• calcium ion binding
• protein phosphatase regulator activity

Cellular components

• ciliary tip
• cilium
• cytosol
• nucleoplasm
• nucleus
• protein phosphatase type 2A complex

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain
• EF-hand domain pair
• EF-Hand 1, calcium-binding site
• PP2A regulatory subunit B'', EF-hand domain
• Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha/beta/delta, EF-hand
• EF-hand domain pair
• EF-hand domain
• P2R3B, EF-hand

KeywordsUniProt

• Calcium
• Metal-binding
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of PPP2R3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOD2
• PPP2CA
• PPP2R1A