Seroatlas · Human Serome Atlas

PPP1R9A

Neurabin-1

Also known as: FLJ20068, KIAA1222, NEB1_HUMAN, Neurabin-I

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULJ8
Gene
PPP1R9A
Ensembl
ENSG00000158528
Chromosome
7
Canonical length
1098 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

1098 residues, UniProt reviewed canonical sequence.

>Q9ULJ8|PPP1R9A
     1  MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG
    61  SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV
   121  SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS
   181  NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS
   241  VTVTNLDTFG HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS
   301  KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGREAAKQQ
   361  RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE
   421  QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND
   481  EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT
   541  EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA
   601  QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS DMAIEVFELP
   661  ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK LQAAENEKVR WELEKTQLQQ
   721  NIEENKERML KLESYWIEAQ TLCHTVNEHL KETQSQYQAL EKKYNKAKKL IKDFQQKELD
   781  FIKRQEAERK KIEDLEKAHL VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS
   841  LGEVSKGDTM ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR
   901  TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS QSLALSSDES
   961  LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL NLEQYVSEFS AQNITGEQLL
  1021  QLDGNKLKAL GMTASQDRAV VKKKLKEMKM SLEKARKAQE KMEKQREKLR RKEQEQMQRK
  1081  SKKTEKMTST TAEGAGEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R9A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • retina: 17 nTPM
  • cerebral cortex: 11 nTPM
  • basal ganglia: 10 nTPM
  • salivary gland: 9.1 nTPM
  • pancreas: 8.3 nTPM
  • hippocampal formation: 7.9 nTPM

Single-cell type

  • salivary acinar cells: 818 nCPM
  • oligodendrocyte progenitor cells: 782 nCPM
  • lacrimal acinar cells: 654 nCPM
  • adrenal cortex cells: 650 nCPM
  • sertoli cells: 585 nCPM
  • rod photoreceptor cells: 584 nCPM

Immune cell

  • NK-cell: 10 nTPM
  • basophil: 6.9 nTPM
  • naive B-cell: 1 nTPM
  • memory B-cell: 0.7 nTPM
  • eosinophil: 0.4 nTPM
  • plasmacytoid DC: 0.3 nTPM

Brain region

  • basal ganglia: 76 nTPM
  • cerebral cortex: 65 nTPM
  • white matter: 63 nTPM
  • hippocampal formation: 60 nTPM
  • hypothalamus: 56 nTPM
  • amygdala: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0
gnomAD missense Z
1.22
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R9A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R9A as an antibody target. Whether an autoantibody or antibody against PPP1R9A could matter depends on whether native PPP1R9A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R9A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R9A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1R9A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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