Seroatlas · Human Serome Atlas

PPP1R14B

Protein phosphatase 1 regulatory subunit 14B

Also known as: PHI-1, PLCB3N, PNG, PP14B_HUMAN, SOM172

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C90
Gene: PPP1R14B
Ensembl: ENSG00000173457
Chromosome: 11
Canonical length: 147 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q96C90|PPP1R14B
     1  MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV RRQGKVTVKY
    61  DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL LDMESDDARA ARVKELLVDC
   121  YKPTEAFISG LLDKIRGMQK LSTPQKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 237 nTPM

Expression across tissuesHPA

Tissue

pancreas: 237 nTPM
esophagus: 225 nTPM
skeletal muscle: 207 nTPM
skin: 160 nTPM
liver: 135 nTPM
heart muscle: 118 nTPM

Single-cell type

pdcs: 874 nCPM
extravillous trophoblasts: 625 nCPM
suprabasal keratinocytes: 217 nCPM
megakaryocytes: 216 nCPM
breast secretory cells: 200 nCPM
respiratory ionocytes: 193 nCPM

Immune cell

plasmacytoid DC: 383 nTPM
memory B-cell: 5 nTPM
neutrophil: 4.9 nTPM
myeloid DC: 4 nTPM
naive B-cell: 3.8 nTPM
intermediate monocyte: 3.1 nTPM

Brain region

thalamus: 41 nTPM
medulla oblongata: 34 nTPM
choroid plexus: 31 nTPM
hypothalamus: 29 nTPM
midbrain: 28 nTPM
cerebellum: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.52
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R14B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LIMK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R14B as an antibody target. Whether an autoantibody or antibody against PPP1R14B could matter depends on whether native PPP1R14B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R14B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R14B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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