Seroatlas · Human Serome Atlas

PPM1H

Protein phosphatase 1H

Also known as: ARHCL1, FLJ13253, KIAA1157, NERPP-2C, PPM1H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULR3
Gene
PPM1H
Ensembl
ENSG00000111110
Chromosome
12
Canonical length
514 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity and phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q9ULR3|PPM1H
     1  MLTRVKSAVA NFMGGIMAGS SGSEHGGGSC GGSDLPLRFP YGRPEFLGLS QDEVECSADH
    61  IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV LTVKKKAGAV TSTPNRNSSK
   121  RRSSLPNGEG LQLKENSESE GVSCHYWSLF DGHAGSGAAV VASRLLQHHI TEQLQDIVDI
   181  LKNSAVLPPT CLGEEPENTP ANSRTLTRAA SLRGGVGAPG SPSTPPTRFF TEKKIPHECL
   241  VIGALESAFK EMDLQIERER SSYNISGGCT ALIVICLLGK LYVANAGDSR AIIIRNGEII
   301  PMSSEFTPET ERQRLQYLAF MQPHLLGNEF THLEFPRRVQ RKELGKKMLY RDFNMTGWAY
   361  KTIEDEDLKF PLIYGEGKKA RVMATIGVTR GLGDHDLKVH DSNIYIKPFL SSAPEVRIYD
   421  LSKYDHGSDD VLILATDGLW DVLSNEEVAE AITQFLPNCD PDDPHRYTLA AQDLVMRARG
   481  VLKDRGWRIS NDRLGSGDDI SVYVIPLIHG NKLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 40 nTPM
  • cerebellum: 35 nTPM
  • retina: 25 nTPM
  • cerebral cortex: 16 nTPM
  • prostate: 13 nTPM
  • hippocampal formation: 12 nTPM

Single-cell type

  • oligodendrocytes: 444 nCPM
  • endometrial glandular cells: 443 nCPM
  • pituitary stem cells: 378 nCPM
  • cone photoreceptor cells: 377 nCPM
  • prostatic glandular cells: 361 nCPM
  • lacrimal acinar cells: 359 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • eosinophil: 1.4 nTPM
  • myeloid DC: 0.9 nTPM
  • classical monocyte: 0.7 nTPM
  • intermediate monocyte: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM

Brain region

  • cerebellum: 70 nTPM
  • thalamus: 42 nTPM
  • hypothalamus: 42 nTPM
  • white matter: 41 nTPM
  • cerebral cortex: 41 nTPM
  • pons: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.79
gnomAD missense Z
1.51
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPM1H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1H as an antibody target. Whether an autoantibody or antibody against PPM1H could matter depends on whether native PPM1H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPM1H. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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