Seroatlas · Human Serome Atlas

PPM1E

Protein phosphatase 1E

Also known as: CaMKP-N, KIAA1072, POPX1, PP2CH, PPM1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WY54
Gene
PPM1E
Ensembl
ENSG00000175175
Chromosome
17
Canonical length
755 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>Q8WY54|PPM1E
     1  MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPEPEPE PEPESEPEPE PELVEAEAAE
    61  ASVEEPGEEA ATVAATEEGD QEQDPEPEEE AAVEGEEEEE GAATAAAAPG HSAVPPPPPQ
   121  LPPLPPLPRP LSERITREEV EGESLDLCLQ QLYKYNCPSF LAAALARATS DEVLQSDLSA
   181  HYIPKETDGT EGTVEIETVK LARSVFSKLH EICCSWVKDF PLRRRPQLYY ETSIHAIKNM
   241  RRKMEDKHVC IPDFNMLFNL EDQEEQAYFA VFDGHGGVDA AIYASIHLHV NLVRQEMFPH
   301  DPAEALCRAF RVTDERFVQK AARESLRCGT TGVVTFIRGN MLHVAWVGDS QVMLVRKGQA
   361  VELMKPHKPD REDEKQRIEA LGGCVVWFGA WRVNGSLSVS RAIGDAEHKP YICGDADSAS
   421  TVLDGTEDYL ILACDGFYDT VNPDEAVKVV SDHLKENNGD SSMVAHKLVA SARDAGSSDN
   481  ITVIVVFLRD MNKAVNVSEE SDWTENSFQG GQEDGGDDKE NHGECKRPWP QHQCSAPADL
   541  GYDGRVDSFT DRTSLSPGSQ INVLEDPGYL DLTQIEASKP HSAQFLLPVE MFGPGAPKKA
   601  NLINELMMEK KSVQSSLPEW SGAGEFPTAF NLGSTGEQIY RMQSLSPVCS GLENEQFKSP
   661  GNRVSRLSHL RHHYSKKWHR FRFNPKFYSF LSAQEPSHKI GTSLSSLTGS GKRNRIRSSL
   721  PWRQNSWKGY SENMRKLRKT HDIPCPDLPW SYKIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • retina: 21 nTPM
  • cerebral cortex: 12 nTPM
  • hippocampal formation: 9.7 nTPM
  • cerebellum: 6.2 nTPM
  • testis: 6.2 nTPM
  • hypothalamus: 5.2 nTPM

Single-cell type

  • cone photoreceptor cells: 1,397 nCPM
  • retinal horizontal cells: 1,254 nCPM
  • brain excitatory neurons: 657 nCPM
  • retinal bipolar cells: 550 nCPM
  • early primary spermatocytes: 438 nCPM
  • other brain neurons: 401 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 94 nTPM
  • cerebral cortex: 81 nTPM
  • thalamus: 29 nTPM
  • hypothalamus: 29 nTPM
  • amygdala: 23 nTPM
  • basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.66
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPM1E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1E as an antibody target. Whether an autoantibody or antibody against PPM1E could matter depends on whether native PPM1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPM1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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