Seroatlas · Human Serome Atlas

PPIH

Peptidyl-prolyl cis-trans isomerase H

Also known as: CYP-20, CYPH, MGC5016, PPIH_HUMAN, SnuCyp-20, USA-CYP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43447
Gene
PPIH
Ensembl
ENSG00000171960
Chromosome
1
Canonical length
177 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>O43447|PPIH
     1  MAVANSSPVN PVVFFDVSIG GQEVGRMKIE LFADVVPKTA ENFRQFCTGE FRKDGVPIGY
    61  KGSTFHRVIK DFMIQGGDFV NGDGTGVASI YRGPFADENF KLRHSAPGLL SMANSGPSTN
   121  GCQFFITCSK CDWLDGKHVV FGKIIDGLLV MRKIENVPTG PNNKPKLPVV ISQCGEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPIH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 56 nTPM
  • bone marrow: 54 nTPM
  • tonsil: 47 nTPM
  • lymph node: 42 nTPM
  • esophagus: 35 nTPM
  • spleen: 33 nTPM

Single-cell type

  • esophageal basal cells: 145 nCPM
  • extravillous trophoblasts: 139 nCPM
  • migrating cytotrophoblasts: 107 nCPM
  • cytotrophoblasts: 87 nCPM
  • early spermatids: 83 nCPM
  • erythrocyte progenitors: 82 nCPM

Immune cell

  • naive CD8 T-cell: 44 nTPM
  • memory CD8 T-cell: 40 nTPM
  • T-reg: 38 nTPM
  • NK-cell: 37 nTPM
  • naive CD4 T-cell: 36 nTPM
  • memory CD4 T-cell: 36 nTPM

Brain region

  • cerebellum: 18 nTPM
  • white matter: 18 nTPM
  • cerebral cortex: 17 nTPM
  • basal ganglia: 17 nTPM
  • thalamus: 17 nTPM
  • pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
1.67
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPIH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPIH as an antibody target. Whether an autoantibody or antibody against PPIH could matter depends on whether native PPIH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPIH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPIH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPIH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...