Seroatlas · Human Serome Atlas

PPFIBP2

Liprin-beta-2

Also known as: Cclp1, LIPB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND30
Gene: PPFIBP2
Ensembl: ENSG00000166387
Chromosome: 11
Canonical length: 876 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

876 residues, UniProt reviewed canonical sequence.

>Q8ND30|PPFIBP2
     1  MASDASHALE AALEQMDGII AGTKTGADLS DGTCEPGLAS PASYMNPFPV LHLIEDLRLA
    61  LEMLELPQER AALLSQIPGP TAAYIKEWFE ESLSQVNHHS AASNETYQER LARLEGDKES
   121  LILQVSVLTD QVEAQGEKIR DLEVCLEGHQ VKLNAAEEML QQELLSRTSL ETQKLDLMTE
   181  VSELKLKLVG MEKEQREQEE KQRKAEELLQ ELRHLKIKVE ELENERNQYE WKLKATKAEV
   241  AQLQEQVALK DAEIERLHSQ LSRTAALHSE SHTERDQEIQ RLKMGMETLL LANEDKDRRI
   301  EELTGLLNQY RKVKEIVMVT QGPSERTLSI NEEEPEGGFS KWNATNKDPE ELFKQEMPPR
   361  CSSPTVGPPP LPQKSLETRA QKKLSCSLED LRSESVDKCM DGNQPFPVLE PKDSPFLAEH
   421  KYPTLPGKLS GATPNGEAAK SPPTICQPDA TGSSLLRLRD TESGWDDTAV VNDLSSTSSG
   481  TESGPQSPLT PDGKRNPKGI KKFWGKIRRT QSGNFYTDTL GMAEFRRGGL RATAGPRLSR
   541  TRDSKGQKSD ANAPFAQWST ERVCAWLEDF GLAQYVIFAR QWVSSGHTLL TATPQDMEKE
   601  LGIKHPLHRK KLVLAVKAIN TKQEEKSALL DHIWVTRWLD DIGLPQYKDQ FHESRVDRRM
   661  LQYLTVNDLL FLKVTSQLHH LSIKCAIHVL HVNKFNPHCL HRRPADESNL SPSEVVQWSN
   721  HRVMEWLRSV DLAEYAPNLR GSGVHGGLII LEPRFTGDTL AMLLNIPPQK TLLRRHLTTK
   781  FNALIGPEAE QEKREKMASP AYTPLTTTAK VRPRKLGFSH FGNIRKKKFD ESTDYICPME
   841  PSDGVSDSHR VYSGYRGLSP LDAPELDGLD QVGQIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPFIBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 63 nTPM
salivary gland: 51 nTPM
stomach: 42 nTPM
choroid plexus: 38 nTPM
thyroid gland: 35 nTPM
epididymis: 33 nTPM

Single-cell type

renal collecting duct intercalated cells: 287 nCPM
endometrial glandular cells: 255 nCPM
choroid plexus epithelial cells: 253 nCPM
retinal pigment epithelial cells: 162 nCPM
prostatic hillock cells: 152 nCPM
adrenal medulla cells: 149 nCPM

Immune cell

non-classical monocyte: 14 nTPM
memory B-cell: 13 nTPM
intermediate monocyte: 11 nTPM
classical monocyte: 9.1 nTPM
myeloid DC: 8.3 nTPM
naive B-cell: 7.2 nTPM

Brain region

choroid plexus: 97 nTPM
white matter: 74 nTPM
basal ganglia: 57 nTPM
thalamus: 53 nTPM
midbrain: 49 nTPM
pons: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -1.12
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

neuromuscular junction development

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPFIBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPFIBP2 as an antibody target. Whether an autoantibody or antibody against PPFIBP2 could matter depends on whether native PPFIBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPFIBP2 is annotated as secreted, so native PPFIBP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PPFIBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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