Seroatlas · Human Serome Atlas

POU6F1

POU domain, class 6, transcription factor 1

Also known as: PO6F1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14863
Gene: POU6F1
Canonical length: 611 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for POU6F1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

611 residues, UniProt reviewed canonical sequence.

>Q14863|POU6F1
     1  MDPGAGSETS LTVNEQVIVM SGHETIRVLE VGVDAQLPAE EESKGLEGVA AEGSQSGDPA
    61  EASQAAGEAG PDNLGSSAEA TVKSPPGIPP SPATAIATFS QAPSQPQASQ TLTPLAVQAA
   121  PQVLTQENLA TVLTGVMVPA GAVTQPLLIP ISIAGQVAGQ QGLAVWTIPT ATVAALPGLT
   181  AASPTGGVFK PPLAGLQAAA VLNTALPAPV QAAAPVQASS TAQPRPPAQP QTLFQTQPLL
   241  QTTPAILPQP TAATAAAPTP KPVDTPPQIT VQPAGFAFSP GIISAASLGG QTQILGSLTT
   301  APVITSAIPS MPGISSQILT NAQGQVIGTL PWVVNSASVA APAPAQSLQV QAVTPQLLLN
   361  AQGQVIATLA SSPLPPPVAV RKPSTPESPA KSEVQPIQPT PTVPQPAVVI ASPAPAAKPS
   421  ASAPIPITCS ETPTVSQLVS KPHTPSLDED GINLEEIREF AKNFKIRRLS LGLTQTQVGQ
   481  ALTATEGPAY SQSAICRFEK LDITPKSAQK LKPVLEKWLN EAELRNQEGQ QNLMEFVGGE
   541  PSKKRKRRTS FTPQAIEALN AYFEKNPLPT GQEITEIAKE LNYDREVVRV WFCNRRQTLK
   601  NTSKLNVFQI P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU6F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 6.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 6.7 nTPM
cerebral cortex: 4.5 nTPM
skeletal muscle: 3.6 nTPM
ovary: 2.6 nTPM
hippocampal formation: 2.5 nTPM
basal ganglia: 2.4 nTPM

Single-cell type

thyrotrophs: 57 nCPM
lactotrophs: 52 nCPM
fibro-adipogenic progenitors: 44 nCPM
bergmann glia: 41 nCPM
rod photoreceptor cells: 41 nCPM
somatotrophs: 34 nCPM

Immune cell

gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 46 nTPM
cerebellum: 41 nTPM
hippocampal formation: 30 nTPM
white matter: 30 nTPM
amygdala: 25 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.88
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POU6F1 as an antibody target. Whether an autoantibody or antibody against POU6F1 could matter depends on whether native POU6F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POU6F1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POU6F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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