Seroatlas · Human Serome Atlas

POU5F1B

POU domain, class 5, transcription factor 1B

Also known as: OTF3C, OTF3P1, P5F1B_HUMAN, POU5F1P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q06416
Gene: POU5F1B
Ensembl: ENSG00000212993
Chromosome: 8
Canonical length: 359 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q06416|POU5F1B
     1  MAGHLASDFA FSPPPGGGGD GPWGAEPGWV DPLTWLSFQG PPGGPGIGPG VGPGSEVWGI
    61  PPCPPPYELC GGMAYCGPQV GVGLVPQGGL ETSQPESEAG VGVESNSNGA SPEPCTVPPG
   121  AVKLEKEKLE QNPEKSQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLI LGVLFGKVFS
   181  QKTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLMQAR KRKRTSIENR
   241  VRGNLENLFL QCPKPTLQIS HIAQQLGLEK DVVRVWFCNR RQKGKRSSSD YAQREDFEAA
   301  GSPFSGGPVS FPPAPGPHFG TPGYGSPHFT ALYSSVPFPE GEVFPPVSVI TLGSPMHSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU5F1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 3.9 nTPM
salivary gland: 1.8 nTPM
kidney: 1.2 nTPM
breast: 0.7 nTPM
prostate: 0.7 nTPM
skin: 0.7 nTPM

Single-cell type

choroid plexus epithelial cells: 3.3 nCPM
endometrial luminal cells: 2.6 nCPM
respiratory ionocytes: 2.5 nCPM
ependymal cells: 1.8 nCPM
parietal cells: 1.8 nCPM
breast lactating cells: 1.7 nCPM

Immune cell

basophil: 1.3 nTPM
gdT-cell: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

choroid plexus: 8.8 nTPM
cerebellum: 5.2 nTPM
hippocampal formation: 3.8 nTPM
cerebral cortex: 3.5 nTPM
midbrain: 3.4 nTPM
medulla oblongata: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POU5F1B as an antibody target. Whether an autoantibody or antibody against POU5F1B could matter depends on whether native POU5F1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POU5F1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POU5F1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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