Seroatlas · Human Serome Atlas

POGK

Pogo transposable element with KRAB domain

Also known as: BASS2, KIAA15131, KRBOX2, LST003, POGK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P215
Gene
POGK
Ensembl
ENSG00000143157
Chromosome
1
Canonical length
609 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The exact function of the protein encoded by this gene is not known. However, this gene product contains a KRAB domain (which is involved in protein-protein interactions) at the N-terminus, and a transposase domain at the C-terminus, suggesting that it may belong to the family of DNA-mediated transposons in human. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q9P215|POGK
     1  MESTAYPLNL SLKEEEEEEE IQSRELEDGP ADMQKVRICS EGGWVPALFD EVAIYFSDEE
    61  WEVLTEQQKA LYREVMRMNY ETVLSLEFPF PKPDMITRLE GEEESQNSDE WQLQGGTSAE
   121  NEESDVKPPD WPNPMNATSQ FPQPQHFDSF GLRLPRDITE LPEWSEGYPF YMAMGFPGYD
   181  LSADDIAGKF QFSRGMRRSY DAGFKLMVVE YAESTNNCQA AKQFGVLEKN VRDWRKVKPQ
   241  LQNAHAMRRA FRGPKNGRFA LVDQRVAEYV RYMQAKGDPI TREAMQLKAL EIAQEMNIPE
   301  KGFKASLGWC RRMMRRYDLS LRHKVPVPQH LPEDLTEKLV TYQRSVLALR RAHDYEVAQM
   361  GNADETPICL EVPSRVTVDN QGEKPVLVKT PGREKLKITA MLGVLADGRK LPPYIILRGT
   421  YIPPGKFPSG MEIRCHRYGW MTEDLMQDWL EVVWRRRTGA VPKQRGMLIL NGFRGHATDS
   481  VKNSMESMNT DMVIIPGGLT SQLQVLDVVV YKPLNDSVRA QYSNWLLAGN LALSPTGNAK
   541  KPPLGLFLEW VMVAWNSISS ESIVQGFKKC HISSNLEEED DVLWEIESEL PGGGEPPKDC
   601  DTESMAESN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POGK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 30 nTPM
  • midbrain: 25 nTPM
  • retina: 25 nTPM
  • hippocampal formation: 22 nTPM
  • amygdala: 21 nTPM
  • basal ganglia: 21 nTPM

Single-cell type

  • alveolar cells type 1: 123 nCPM
  • retinal horizontal cells: 64 nCPM
  • platelets: 54 nCPM
  • rod photoreceptor cells: 50 nCPM
  • alveolar cells type 2: 45 nCPM
  • transitional alveolar cells: 44 nCPM

Immune cell

  • non-classical monocyte: 9.1 nTPM
  • myeloid DC: 7.8 nTPM
  • intermediate monocyte: 7.5 nTPM
  • NK-cell: 7.5 nTPM
  • memory B-cell: 6.7 nTPM
  • classical monocyte: 6 nTPM

Brain region

  • white matter: 62 nTPM
  • basal ganglia: 54 nTPM
  • midbrain: 50 nTPM
  • medulla oblongata: 47 nTPM
  • spinal cord: 46 nTPM
  • thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.89
gnomAD missense Z
3.35
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POGK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POGK as an antibody target. Whether an autoantibody or antibody against POGK could matter depends on whether native POGK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POGK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POGK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POGK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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