Seroatlas · Human Serome Atlas

PNPLA7

Patatin-like phospholipase domain-containing protein 7

Also known as: C9orf111, FLJ31318, FLJ43070, FLJ44279, NTE-R1, NTEL1, PLPL7_HUMAN, RP11-48C7.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZV29
Gene: PNPLA7
Ensembl: ENSG00000130653
Chromosome: 9
Canonical length: 1317 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]

Canonical amino-acid sequenceUniProt

1317 residues, UniProt reviewed canonical sequence.

>Q6ZV29|PNPLA7
     1  MEEEKDDSPQ LTGIAVGALL ALALVGVLIL FMFRRLRQFR QAQPTPQYRF RKRDKVMFYG
    61  RKIMRKVTTL PNTLVENTAL PRQRARKRTK VLSLAKRILR FKKEYPALQP KEPPPSLLEA
   121  DLTEFDVKNS HLPSEVLYML KNVRVLGHFE KPLFLELCKH IVFVQLQEGE HVFQPREPDP
   181  SICVVQDGRL EVCIQDTDGT EVVVKEVLAG DSVHSLLSIL DIITGHAAPY KTVSVRAAIP
   241  STILRLPAAA FHGVFEKYPE TLVRVVQIIM VRLQRVTFLA LHNYLGLTTE LFNAESQAIP
   301  LVSVASVAAG KAKKQVFYGE EERLKKPPRL QESCDSDHGG GRPAAAGPLL KRSHSVPAPS
   361  IRKQILEELE KPGAGDPDPS APQGGPGSAT SDLGMACDRA RVFLHSDEHP GSSVASKSRK
   421  SVMVAEIPST VSQHSESHTD ETLASRKSDA IFRAAKKDLL TLMKLEDSSL LDGRVALLHV
   481  PAGTVVSRQG DQDASILFVV SGLLHVYQRK IGSQEDTCLF LTRPGEMVGQ LAVLTGEPLI
   541  FTVKANRDCS FLSISKAHFY EIMRKQPTVV LGVAHTVVKR MSSFVRQIDF ALDWVEVEAG
   601  RAIYRQGDKS DCTYIMLSGR LRSVIRKDDG KKRLAGEYGR GDLVGVVETL THQARATTVH
   661  AVRDSELAKL PAGALTSIKR RYPQVVTRLI HLLGEKILGS LQQGPVTGHQ LGLPTEGSKW
   721  DLGNPAVNLS TVAVMPVSEE VPLTAFALEL EHALSAIGPT LLLTSDNIKR RLGSAALDSV
   781  HEYRLSSWLG QQEDTHRIVL YQADGTLTPW TQRCVRQADC ILIVGLGDQE PTVGELERML
   841  ESTAVRAQKQ LILLHREEGP APARTVEWLN MRSWCSGHLH LCCPRRVFSR RSLPKLVEMY
   901  KHVFQRPPDR HSDFSRLARV LTGNAIALVL GGGGARGCAQ VGVLKALAEC GIPVDMVGGT
   961  SIGAFVGALY SEERNYSQMR IRAKQWAEGM TSLMKAALDL TYPITSMFSG AGFNSSIFSV
  1021  FKDQQIEDLW IPYFAITTDI TASAMRVHTD GSLWWYVRAS MSLSGYMPPL CDPKDGHLLM
  1081  DGGYINNLPA DVARSMGAKV VIAIDVGSRD ETDLTNYGDA LSGWWLLWKR WNPLATKVKV
  1141  LNMAEIQTRL AYVCCVRQLE VVKSSDYCEY LRPPIDSYST LDFGKFNEIC EVGYQHGRTV
  1201  FDIWGRSGVL EKMLRDQQGP SKKPASAVLT CPNASFTDLA EIVSRIEPAK PAMVDDESDY
  1261  QTEYEEELLD VPRDAYADFQ STSAQQGSDL EDESSLRHRH PSLAFPKLSE GSSDQDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNPLA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

prostate: 22 nTPM
ovary: 21 nTPM
pancreas: 17 nTPM
thyroid gland: 17 nTPM
skeletal muscle: 16 nTPM
stomach: 16 nTPM

Single-cell type

prostatic glandular cells: 116 nCPM
myonuclei: 98 nCPM
rod photoreceptor cells: 86 nCPM
astrocytes: 83 nCPM
adipocytes: 78 nCPM
proximal tubule cells: 69 nCPM

Immune cell

T-reg: 1.2 nTPM
naive B-cell: 1 nTPM
naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM

Brain region

hippocampal formation: 18 nTPM
white matter: 16 nTPM
cerebral cortex: 15 nTPM
basal ganglia: 15 nTPM
amygdala: 15 nTPM
medulla oblongata: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PNPLA7.

Disease | ImmuneIEDB

Conditions an epitope on PNPLA7 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphatidylcholine catabolic process

Molecular functions

phosphatidylcholine lysophospholipase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNPLA7 as an antibody target. Whether an autoantibody or antibody against PNPLA7 could matter depends on whether native PNPLA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNPLA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNPLA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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