Seroatlas · Human Serome Atlas

PNPLA5

Patatin-like phospholipase domain-containing protein 5

Also known as: dJ388M5.4, GS2L, PLPL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6Z6
Gene: PNPLA5
Ensembl: ENSG00000100341
Chromosome: 22
Canonical length: 429 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mid piece,Annulus

OverviewNCBI Gene

This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q7Z6Z6|PNPLA5
     1  MGFLEEEGRW NLSFSGAGYL GAHHVGATEC LRQRAPRLLQ GARRIYGSSS GALNAVSIVC
    61  GKSVDFCCSH LLGMVGQLER LSLSILHPAY APIEHVKQQL QDALPPDAHV LASQRLGISL
   121  TRWPDGRNFL VTDFATCDEL IQALVCTLYF PFYCGLIPPE FRGERYIDGA LSNNLPFADC
   181  PSTITVSPFH GTVDICPQST SPNLHELNVF NFSFQISTEN FFLGLICLIP PSLEVVADNC
   241  RQGYLDALRF LERRGLTKEP VLWTLVSKEP PAPADGNWDA GCDQRWKGGL SLNWKVPHVQ
   301  VKDVPNFEQL SPELEAALKK ACTRDPSRWA RFWHSGPGQV LTYLLLPCTL PFEYIYFRSR
   361  RLVVWLPDVP ADLWWMQGLL RNMALEVFSR TKAQLLGPIS PPATRVLETS PLQPQIAPHR
   421  EELGPTHQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNPLA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

skin: 2.9 nTPM
basal ganglia: 2.6 nTPM
epididymis: 1.6 nTPM
cerebral cortex: 1.2 nTPM
liver: 0.9 nTPM
pituitary gland: 0.8 nTPM

Single-cell type

epididymal principal cells: 11 nCPM
somatotrophs: 8.1 nCPM
brain inhibitory neurons: 4.6 nCPM
retinal pigment epithelial cells: 4.3 nCPM
epididymal efferent duct absorptive cells: 3.8 nCPM
lactotrophs: 3.1 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 10 nTPM
cerebral cortex: 8.4 nTPM
hippocampal formation: 5.7 nTPM
medulla oblongata: 4.8 nTPM
hypothalamus: 4.6 nTPM
midbrain: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

triacylglycerol lipase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNPLA5 as an antibody target. Whether an autoantibody or antibody against PNPLA5 could matter depends on whether native PNPLA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNPLA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNPLA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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