Seroatlas · Human Serome Atlas

PMIS2

Transmembrane protein PMIS2

Also known as: IFITMD9, PMIS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PS18
Gene
PMIS2
Ensembl
ENSG00000283758
Chromosome
19
Canonical length
150 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>A0A1W2PS18|PMIS2
     1  MALKPPSATQ PAPNAPATPD APPTTGDPGA SAAPGSPTTT GGPGAPAEVP QEPQEPTQTP
    61  EELAFYAPNY LCLTIFAILL FPPFGLAALY FSYEGSWTQK PTSMLPPLQT MKANQNSEWE
   121  EAYINSGRTG WFGAFVVMIG LGIIYGLVLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMIS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.7 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late spermatids: 34 nCPM
  • early spermatids: 15 nCPM
  • late primary spermatocytes: 12 nCPM
  • early primary spermatocytes: 0.3 nCPM
  • cdc: 0.1 nCPM
  • gonadotrophs: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 3.6 nTPM
  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMIS2 as an antibody target. Whether an autoantibody or antibody against PMIS2 could matter depends on whether native PMIS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMIS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMIS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PMIS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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