Seroatlas · Human Serome Atlas

PMEPA1

Protein TMEPAI

Also known as: PMEPA_HUMAN, STAG1, TMEPAI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969W9
Gene
PMEPA1
Ensembl
ENSG00000124225
Chromosome
20
Canonical length
287 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q969W9|PMEPA1
     1  MHRLMGVNST AAAAAGQPNV SCTCNCKRSL FQSMEITELE FVQIIIIVVV MMVMVVVITC
    61  LLSHYKLSAR SFISRHSQGR RREDALSSEG CLWPSESTVS GNGIPEPQVY APPRPTDRLA
   121  VPPFAQRERF HRFQPTYPYL QHEIDLPPTI SLSDGEEPPP YQGPCTLQLR DPEQQLELNR
   181  ESVRAPPNRT IFDSDLMDSA RLGGPCPPSS NSGISATCYG SGGRMEGPPP TYSEVIGHYP
   241  GSSFQHQQSS GPPSLLEGTR LHHTHIAPLE SAAIWSKEKD KQKGHPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMEPA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
128 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 128 nTPM
  • prostate: 103 nTPM
  • cervix: 88 nTPM
  • adipose tissue: 47 nTPM
  • basal ganglia: 47 nTPM
  • endometrium: 41 nTPM

Single-cell type

  • pancreatic duct cells: 905 nCPM
  • prostatic glandular cells: 765 nCPM
  • müller glia: 477 nCPM
  • schwann cells: 459 nCPM
  • alveolar cells type 1: 339 nCPM
  • salivary basal cells: 297 nCPM

Immune cell

  • plasmacytoid DC: 24 nTPM
  • naive B-cell: 6.3 nTPM
  • memory B-cell: 2.6 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.2 nTPM
  • memory CD4 T-cell: 0.8 nTPM

Brain region

  • basal ganglia: 173 nTPM
  • pons: 99 nTPM
  • cerebellum: 98 nTPM
  • thalamus: 94 nTPM
  • midbrain: 90 nTPM
  • medulla oblongata: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.94
gnomAD missense Z
1.21
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PMEPA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMEPA1 as an antibody target. Whether an autoantibody or antibody against PMEPA1 could matter depends on whether native PMEPA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMEPA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMEPA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PMEPA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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