Seroatlas · Human Serome Atlas

PLIN4

Perilipin-4

Also known as: KIAA1881, PLIN4_HUMAN, S3-12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96Q06
Gene
PLIN4
Ensembl
ENSG00000167676
Chromosome
19
Canonical length
1371 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Lipid droplets,Plasma membrane,Cytosol

OverviewNCBI Gene

Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

1371 residues, UniProt reviewed canonical sequence.

>Q96Q06|PLIN4
     1  MSAPDEGRRD PPKPKGKTLG SFFGSLPGFS SARNLVANAH SSARARPAAD PTGAPAAEAA
    61  QPQAQVAAHP EQTAPWTEKE LQPSEKMVSG AKDLVCSKMS RAKDAVSSGV ASVVDVAKGV
   121  VQGGLDTTRS ALTGTKEVVS SGVTGAMDMA KGAVQGGLDT SKAVLTGTKD TVSTGLTGAV
   181  NVAKGTVQAG VDTTKTVLTG TKDTVTTGVM GAVNLAKGTV QTGVETSKAV LTGTKDAVST
   241  GLTGAVNVAR GSIQTGVDTS KTVLTGTKDT VCSGVTGAMN VAKGTIQTGV DTSKTVLTGT
   301  KDTVCSGVTG AMNVAKGTIQ TGVDTSKTVL TGTKDTVCSG VTGAMNVAKG TIQTGVDTTK
   361  TVLTGTKNTV CSGVTGAVNL AKEAIQGGLD TTKSMVMGTK DTMSTGLTGA ANVAKGAMQT
   421  GLNTTQNIAT GTKDTVCSGV TGAMNLARGT IQTGVDTTKI VLTGTKDTVC SGVTGAANVA
   481  KGAVQGGLDT TKSVLTGTKD AVSTGLTGAV NVAKGTVQTG VDTTKTVLTG TKDTVCSGVT
   541  SAVNVAKGAV QGGLDTTKSV VIGTKDTMST GLTGAANVAK GAVQTGVDTA KTVLTGTKDT
   601  VTTGLVGAVN VAKGTVQTGM DTTKTVLTGT KDTIYSGVTS AVNVAKGAVQ TGLKTTQNIA
   661  TGTKNTFGSG VTSAVNVAKG AAQTGVDTAK TVLTGTKDTV TTGLMGAVNV AKGTVQTSVD
   721  TTKTVLTGTK DTVCSGVTGA ANVAKGAIQG GLDTTKSVLT GTKDAVSTGL TGAVKLAKGT
   781  VQTGMDTTKT VLTGTKDAVC SGVTGAANVA KGAVQMGVDT AKTVLTGTKD TVCSGVTGAA
   841  NVAKGAVQTG LKTTQNIATG TKNTLGSGVT GAAKVAKGAV QGGLDTTKSV LTGTKDAVST
   901  GLTGAVNLAK GTVQTGVDTS KTVLTGTKDT VCSGVTGAVN VAKGTVQTGV DTAKTVLSGA
   961  KDAVTTGVTG AVNVAKGTVQ TGVDASKAVL MGTKDTVFSG VTGAMSMAKG AVQGGLDTTK
  1021  TVLTGTKDAV SAGLMGSGNV ATGATHTGLS TFQNWLPSTP ATSWGGLTSS RTTDNGGEQT
  1081  ALSPQEAPFS GISTPPDVLS VGPEPAWEAA ATTKGLATDV ATFTQGAAPG REDTGLLATT
  1141  HGPEEAPRLA MLQNELEGLG DIFHPMNAEE QAQLAASQPG PKVLSAEQGS YFVRLGDLGP
  1201  SFRQRAFEHA VSHLQHGQFQ ARDTLAQLQD CFRLIEKAQQ APEGQPRLDQ GSGASAEDAA
  1261  VQEERDAGVL SRVCGLLRQL HTAYSGLVSS LQGLPAELQQ PVGRARHSLC ELYGIVASAG
  1321  SVEELPAERL VQSREGVHQA WQGLEQLLEG LQHNPPLSWL VGPFALPAGG Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
716 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 716 nTPM
  • breast: 303 nTPM
  • skeletal muscle: 236 nTPM
  • tongue: 151 nTPM
  • heart muscle: 105 nTPM
  • liver: 90 nTPM

Single-cell type

  • adipocytes: 518 nCPM
  • myonuclei: 57 nCPM
  • hepatocytes: 36 nCPM
  • smooth muscle cells: 27 nCPM
  • cardiomyocytes: 24 nCPM
  • epicardial cells: 21 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • thalamus: 23 nTPM
  • medulla oblongata: 20 nTPM
  • midbrain: 19 nTPM
  • basal ganglia: 18 nTPM
  • spinal cord: 17 nTPM
  • amygdala: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLIN4.

Disease | AllUniProt

Conditions PLIN4 is implicated in, by any mechanism.

  • Myopathy with rimmed ubiquitin-positive autophagic vacuolation, autosomal dominant (MRUPAV) MIM:601846

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 368 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Vacuolar Neuromyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
-1.68
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLIN4 as an antibody target. Whether an autoantibody or antibody against PLIN4 could matter depends on whether native PLIN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLIN4 is annotated at the cell surface, where native PLIN4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLIN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLIN4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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