Seroatlas · Human Serome Atlas

PLEKHO2

Pleckstrin homology domain-containing family O member 2

Also known as: DKFZp761K2312, PKHO2_HUMAN, PLEKHQ1, PP1628, pp9099

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD55
Gene: PLEKHO2
Ensembl: ENSG00000241839
Chromosome: 15
Canonical length: 490 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in macrophage apoptotic process. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q8TD55|PLEKHO2
     1  MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV YENEDDQKCV
    61  ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ APTGEEKESW IKALNEGINR
   121  GKNKAFDEVK VDKSCALEHV TRDRVRGGQR RRPPTRVHLK EVASAASDGL LRLDLDVPDS
   181  GPPVFAPSNH VSEAQPRETP RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV
   241  SPESQEDSET PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE
   301  AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP EPAKPSQAEG
   361  TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR HPLQPRERLY RAQLEVKVAS
   421  EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ LRQATQVLQE MRDLGELSQE APGLREKRKE
   481  LVTLYRRSAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

spleen: 98 nTPM
bone marrow: 49 nTPM
lung: 40 nTPM
adipose tissue: 36 nTPM
lymph node: 32 nTPM
adrenal gland: 31 nTPM

Single-cell type

retinal pigment epithelial cells: 4.3 nCPM
neutrophils: 1.6 nCPM
early spermatids: 1.2 nCPM
myosatellite cells: 1.2 nCPM
adipocytes: 0.9 nCPM
müller glia: 0.8 nCPM

Immune cell

neutrophil: 78 nTPM
non-classical monocyte: 73 nTPM
intermediate monocyte: 52 nTPM
classical monocyte: 43 nTPM
total PBMC: 36 nTPM
myeloid DC: 27 nTPM

Brain region

medulla oblongata: 44 nTPM
thalamus: 36 nTPM
spinal cord: 35 nTPM
basal ganglia: 32 nTPM
pons: 32 nTPM
midbrain: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.03
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

macrophage apoptotic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CAPZB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHO2 as an antibody target. Whether an autoantibody or antibody against PLEKHO2 could matter depends on whether native PLEKHO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHO2 is annotated as secreted, so native PLEKHO2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PLEKHO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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