Seroatlas · Human Serome Atlas

PLEKHA2

Pleckstrin homology domain-containing family A member 2

Also known as: PKHA2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB19
Gene: PLEKHA2
Canonical length: 425 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PLEKHA2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q9HB19|PLEKHA2
     1  MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA MGAGAVGALQ
    61  LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD MKDWVEALNQ ASKITVPKGG
   121  GLPMTTEVLK SLAAPPALEK KPQVAYKTEI IGGVVVHTPI SQNGGDGQEG SEPGSHTILR
   181  RSQSYIPTSG CRASTGPPLI KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR
   241  TIFLKDVLKT HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL
   301  KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV ASSWQPWTPV
   361  PQAGEKLLPP GDTSEDSLFT PRPGEGSAPG VLPSSRIRHR SEPQHPKEKP FMFNLDDENI
   421  RTSDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

lymph node: 74 nTPM
tonsil: 62 nTPM
spleen: 41 nTPM
heart muscle: 40 nTPM
bone marrow: 38 nTPM
appendix: 33 nTPM

Single-cell type

neutrophil progenitors: 345 nCPM
b-cells: 322 nCPM
innate lymphoid cells: 274 nCPM
renal collecting duct principal cells: 271 nCPM
nk-cells: 266 nCPM
podocytes: 252 nCPM

Immune cell

naive B-cell: 13 nTPM
memory B-cell: 10 nTPM
eosinophil: 8.1 nTPM
basophil: 6.9 nTPM
plasmacytoid DC: 5.4 nTPM
NK-cell: 3.9 nTPM

Brain region

hippocampal formation: 64 nTPM
cerebral cortex: 49 nTPM
white matter: 46 nTPM
amygdala: 40 nTPM
choroid plexus: 39 nTPM
medulla oblongata: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.84
gnomAD missense Z: 2.08

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of cell-matrix adhesion

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHA2 as an antibody target. Whether an autoantibody or antibody against PLEKHA2 could matter depends on whether native PLEKHA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHA2 is annotated at the cell surface, where native PLEKHA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...