Seroatlas · Human Serome Atlas

PLA2G4C

Cytosolic phospholipase A2 gamma

Also known as: cPLA2-gamma, PA24C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UP65
Gene
PLA2G4C
Ensembl
ENSG00000105499
Chromosome
19
Canonical length
541 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q9UP65|PLA2G4C
     1  MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG GGLRAHIACL
    61  GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA LEADLKHRFT RQEWDLAKSL
   121  QKTIQAARSE NYSLTDFWAY MVISKQTREL PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ
   181  PSWQEARAPE TWFEFTPHHA GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG
   241  SALGNTEVIR EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
   301  EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI CASKWEWGTT
   361  HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP TREVHLILSF DFSAGDPFET
   421  IRATTDYCRR HKIPFPQVEE AELDLWSKAP ASCYILKGET GPVVMHFPLF NIDACGGDIE
   481  AWSDTYDTFK LADTYTLDVV VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL
   541  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • retina: 73 nTPM
  • skeletal muscle: 63 nTPM
  • tongue: 38 nTPM
  • heart muscle: 24 nTPM
  • spinal cord: 19 nTPM
  • midbrain: 19 nTPM

Single-cell type

  • myonuclei: 462 nCPM
  • rod photoreceptor cells: 289 nCPM
  • retinal bipolar cells: 178 nCPM
  • bergmann glia: 176 nCPM
  • oligodendrocytes: 153 nCPM
  • pancreatic duct cells: 122 nCPM

Immune cell

  • intermediate monocyte: 5.8 nTPM
  • memory B-cell: 4.1 nTPM
  • classical monocyte: 2.1 nTPM
  • non-classical monocyte: 1.4 nTPM
  • total PBMC: 1.4 nTPM
  • myeloid DC: 1.2 nTPM

Brain region

  • white matter: 87 nTPM
  • pons: 57 nTPM
  • medulla oblongata: 53 nTPM
  • midbrain: 50 nTPM
  • basal ganglia: 50 nTPM
  • cerebral cortex: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.17
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G4C as an antibody target. Whether an autoantibody or antibody against PLA2G4C could matter depends on whether native PLA2G4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G4C is annotated at the cell surface, where native PLA2G4C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G4C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...