Seroatlas · Human Serome Atlas

PIPSL

Putative PIP5K1A and PSMD4-like protein

Also known as: PIPSL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2A3N6
Gene: PIPSL
Canonical length: 862 aa

OverviewNCBI Gene

No narrative summary is available for PIPSL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

862 residues, UniProt reviewed canonical sequence.

>A2A3N6|PIPSL
     1  MASEVPYASG MPIKKIGHRS VDSSGGTTSS ALKGAIQLGI THTVGSLSTK PESDVLMQDF
    61  HMVESIFFPS EGSNLTPAHH YNAFRFKTYA PVAFRYFWEL FGIRPDDYLY SLCSEPLIEL
   121  CSSGASGSLF YVSSDDEFIV KTVRHKEAEF LQKLLPGYYI NLNQNPRTLL PKFYGLYCVQ
   181  TGGKNIRIVV MNNLLPRSVK MHIKYDLKGS TYRRRASQKE REKPLPTFKD LDFLQDIPDG
   241  LFLDADVHNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP
   301  APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK
   361  KLEHSWKALI HDGDTVSVHR PGFYAEWFQR FMCNTVFKKI PLKPSPSKKL RSGSSFSQRA
   421  GSSGNSCITY QPLVSGEHKA QVTTKAEVEP GVHLGCPDVL PQTPPLEEIS EGSPTPDPSF
   481  SPLVEETLQM LTTSVDNSEY MGNGDFLPTR LQAQQDAVNT VCHSKTRSNP ENNVGLITLD
   541  NDCEVLTTLT PDTGRILSKL HTVQPKGKIT FCMGIHVAHL ALKHRQGNNH KIRIIAFVGN
   601  PVEDNEKNLV KLAKCLKKEK VNVDIINFGE EEVNTEKLTA FVNTLNGKDG TGSHLVTVPP
   661  GPSLADALIS FPILAGEGGA MMGLGASDFE FGVDPSADPE LALVLRVFME EQRQRQEEEA
   721  RQAAAASAAE AGIATTGTED SDDALLKMTI SQQEFGHTGL PDLSSMTEEE KIVCAMQMSL
   781  QGAEFGLAES ADIDASSAMD TSEPAKEEDD YDVMQDPEFL QSVLENLPGV DPNNEAIRNA
   841  VGSLASQATK DSKKDKKEED KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIPSL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

1-phosphatidylinositol-4-phosphate 5-kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIPSL as an antibody target. Whether an autoantibody or antibody against PIPSL could matter depends on whether native PIPSL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIPSL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIPSL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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