Seroatlas · Human Serome Atlas

PIP5KL1

Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

Also known as: bA203J24.5, MGC46424, PI5L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T9C9
Gene: PIP5KL1
Ensembl: ENSG00000167103
Chromosome: 9
Canonical length: 394 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q5T9C9|PIP5KL1
     1  MAAPSPGPRE VLAPSPEAGC RAVTSSRRGL LWRLRDKQSR LGLFEISPGH ELHGMTCMMQ
    61  AGLWAATQVS MDHPPTGPPS RDDFSEVLTQ VHEGFELGTL AGPAFAWLRR SLGLAEEDYQ
   121  AALGPGGPYL QFLSTSKSKA SFFLSHDQRF FLKTQGRREV QALLAHLPRY VQHLQRHPHS
   181  LLARLLGVHS LRVDRGKKTY FIVMQSVFYP AGRISERYDI KGCEVSRWVD PAPEGSPLVL
   241  VLKDLNFQGK TINLGPQRSW FLRQMELDTT FLRELNVLDY SLLIAFQRLH EDERGPGSSL
   301  IFRTARSVQG AQSPEESRAQ NRRLLPDAPN ALHILDGPEQ RYFLGVVDLA TVYGLRKRLE
   361  HLWKTLRYPG RTFSTVSPAR YARRLCQWVE AHTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP5KL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 3.7 nTPM

Expression across tissuesHPA

Tissue

skin: 3.7 nTPM
pituitary gland: 3.6 nTPM
vagina: 3.4 nTPM
cervix: 3 nTPM
esophagus: 3 nTPM
salivary gland: 3 nTPM

Single-cell type

late spermatids: 40 nCPM
conjunctival goblet cells: 36 nCPM
early spermatids: 25 nCPM
foveolar cells: 19 nCPM
endometrial glandular cells: 13 nCPM
endometrial secretory cells: 11 nCPM

Immune cell

naive B-cell: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

pons: 5.9 nTPM
cerebral cortex: 4.5 nTPM
medulla oblongata: 4.5 nTPM
cerebellum: 4.2 nTPM
thalamus: 3.6 nTPM
hypothalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIP5KL1 as an antibody target. Whether an autoantibody or antibody against PIP5KL1 could matter depends on whether native PIP5KL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIP5KL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIP5KL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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