PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Also known as: EPVH, PAR14, PAR17, PIN4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y237
- Gene
- PIN4
- Ensembl
- ENSG00000102309
- Chromosome
- X
- Canonical length
- 131 aa
- Protein class
- Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Mitotic chromosome
OverviewNCBI Gene
This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Canonical amino-acid sequenceUniProt
131 residues, UniProt reviewed canonical sequence.
>Q9Y237|PIN4
1 MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK IMEAMEKLKS
61 GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA LPVSGMDKPV FTDPPVKTKF
121 GYHIIMVEGR KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PIN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- liver: 27 nTPM
- kidney: 25 nTPM
- amygdala: 22 nTPM
- choroid plexus: 22 nTPM
- spinal cord: 22 nTPM
- cerebral cortex: 21 nTPM
Single-cell type
- thymocytes: 422 nCPM
- mesothelial cells: 311 nCPM
- esophageal apical cells: 293 nCPM
- hepatocytes: 279 nCPM
- cytotrophoblasts: 195 nCPM
- plasma cells: 188 nCPM
Immune cell
- T-reg: 58 nTPM
- memory B-cell: 49 nTPM
- naive B-cell: 46 nTPM
- naive CD8 T-cell: 45 nTPM
- plasmacytoid DC: 45 nTPM
- naive CD4 T-cell: 44 nTPM
Brain region
- white matter: 13 nTPM
- cerebellum: 13 nTPM
- hypothalamus: 12 nTPM
- medulla oblongata: 12 nTPM
- cerebral cortex: 11 nTPM
- midbrain: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.73
- gnomAD pLI
- 0.71
- gnomAD missense Z
- -0.12
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- bent DNA binding
- DNA binding
- double-stranded DNA binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Peptidyl-prolyl cis-trans isomerase, PpiC-type
- Peptidyl-prolyl cis-trans isomerase domain superfamily
- Peptidyl-prolyl cis-trans isomerase PIN4
- PPIC-type PPIASE domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PIN4 as an antibody target. Whether an autoantibody or antibody against PIN4 could matter depends on whether native PIN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PIN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PIN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...