Seroatlas · Human Serome Atlas

PHF11

PHD finger protein 11

Also known as: BCAP, IGER, NY-REN-34, PHF11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UIL8
Gene: PHF11
Ensembl: ENSG00000136147
Chromosome: 13
Canonical length: 331 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9UIL8|PHF11
     1  MAQASPPRPE RVLGASSPEA RPAQEALLLP TGVFQVAEKM EKRTCALCPK DVEYNVLYFA
    61  QSENIAAHEN CLLYSSGLVE CEDQDPLNPD RSFDVESVKK EIQRGRKLKC KFCHKRGATV
   121  GCDLKNCNKN YHFFCAKKDD AVPQSDGVRG IYKLLCQQHA QFPIIAQSAK FSGVKRKRGR
   181  KKPLSGNHVQ PPETMKCNTF IRQVKEEHGR HTDATVKVPF LKKCKEAGLL NYLLEEILDK
   241  VHSIPEKLMD ETTSESDYEE IGSALFDCRL FEDTFVNFQA AIEKKIHASQ QRWQQLKEEI
   301  ELLQDLKQTL CSFQENRDLM SSSTSISSLS Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

lymph node: 41 nTPM
adrenal gland: 37 nTPM
salivary gland: 37 nTPM
spleen: 37 nTPM
tonsil: 37 nTPM
bone marrow: 35 nTPM

Single-cell type

late spermatids: 97 nCPM
microglia: 82 nCPM
decidual stromal cells: 79 nCPM
neutrophils: 75 nCPM
extravillous trophoblasts: 74 nCPM
t-cells: 73 nCPM

Immune cell

T-reg: 78 nTPM
intermediate monocyte: 54 nTPM
memory CD4 T-cell: 54 nTPM
neutrophil: 52 nTPM
non-classical monocyte: 52 nTPM
memory CD8 T-cell: 51 nTPM

Brain region

medulla oblongata: 23 nTPM
spinal cord: 21 nTPM
white matter: 21 nTPM
pons: 20 nTPM
hypothalamus: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF11 as an antibody target. Whether an autoantibody or antibody against PHF11 could matter depends on whether native PHF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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